4-Methyl-hexin-(1)-ol-(4) | 19135-01-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methyl-hexin-(1)-ol-(4)
• 英文别名: 3-Methyl-5-hexyn-3-ol；3-Methylhex-5-yn-3-ol
• CAS: 19135-01-4
• 化学式: C₇H₁₂O
• mdl: MFCD18296123
• 分子量: 112.172
• InChiKey: DQZBGZSZYNWHEP-UHFFFAOYSA-N

物化性质

• 沸点：
  78-79 °C(Press: 63 Torr)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methyl-hexin-(1)-ol-(4) 在 乙基溴化镁 作用下， 以 四氢呋喃 为溶剂， 生成 4-Hydroxy-4-methylhex-1-in-1-carbonsaeure-methylester
  参考文献：
  名称：

  Vereshchagin,L.I. et al., Journal of Organic Chemistry USSR (English Translation), 1973, vol. 9, # 2, p. 245 - 249

  摘要：

  DOI：
• 作为产物：
  描述：

  3-溴丙炔 在 四氢呋喃 、 aluminium amalgam 作用下， 生成 4-Methyl-hexin-(1)-ol-(4)
  参考文献：
  名称：

  The Prevalence of Daytime Napping and Its Relationship to Nighttime Sleep

  摘要：

  Many healthy adults report daytime napping. Surprisingly few studies, however have examined spontaneous napping behavior especially very short naps, in healthy adults. The authors examined the prevalence of power naps (lasting less than 20 minutes) and longer naps (20 minutes or more) and their effects on nighttime sleep in a group of healthy young and middle-aged adults. The young and middle-aged adults reported very similar sleep and napping patterns, with approximately 74% of the participants in both groups reporting they had napped during a 7-day sleep-log period. Almost half of the participants reported that the average nap lasted less than 20 minutes. A multivariant analysis of variance (MANOVA) found no significant differences between the no-nap and the power-nap or long-nap groups in sleep quantity or quality for either age group. The current data suggested that power napping occurs frequently in healthy adults and that spontaneous napping does not negatively affect nighttime sleep.

  DOI：

  10.1080/08964280109595773

文献信息

• Substituierte Propargylcarbinole und ihre hypnotische Wirkung
  作者：H. Gutmann、O. Isler、G. Ryser、P. Zeller、B. Pellmont

  DOI：10.1002/hlca.19590420312

  日期：——

  Thirty tertiary propargylic carbinols have been prepared by condensing propargyl bromide with ketones. Some of them showed better hypnotic activity than 3-methylpentyn-3-01. The best compound of the series was 1-chloro-2-chloromethylpent-4-yn-2-01 which proved to be a very effective hypnotic with a favourable therapeutic index.

  通过使炔丙基溴与酮缩合制备了三十种叔炔丙基甲醇。其中一些表现出比3-甲基戊炔-3-01更好的催眠活性。该系列中最好的化合物是1-氯-2-氯甲基戊-4-yn-2-01，事实证明它是一种非常有效的催眠药，具有良好的治疗指数。
• <i>B</i>-Allenyl- and <i>B-</i>(γ-Trimethylsilylpropargyl)- 10-phenyl-9-borabicyclo[3.3.2]decanes:  Asymmetric Synthesis of Propargyl and α-Allenyl 3°-Carbinols from Ketones
  作者：Eliud Hernandez、Carlos H. Burgos、Eyleen Alicea、John A. Soderquist

  DOI：10.1021/ol061596j

  日期：2006.8.1

  Simple and efficient Grignard procedures are reported for the syntheses of B-allenyl-10-(phenyl)-9-borabicyclo[3.3.2]decane (1) and its B-(gamma-trimethylsilylpropargyl) counterpart (2) in both enantiomeric forms. Both add selectively to ketones, providing propargyl- and alpha-silylallenyl 3-degree-carbinols, respectively (i.e., 6 (61-93% ee) and 9 (64-98% ee)). The air-stable boron byproduct is efficiently

  据报道，简单有效的Grignard方法可合成两种对映体形式的B-烯基-10-（苯基）-9-环硼[3.3.2]癸烷（1）及其对应的B-（γ-三甲基甲硅烷基炔丙基）（2）。 。两者都选择性地添加到酮中，分别提供炔丙基和α-甲硅烷基烯丙基3-度羰基化合物（即6（61-93％ee）和9（64-98％ee））。空气稳定的硼副产物可有效回收并循环回1或2。9的臭氧分解和溴化分别提供非外消旋的α-羟基酸和γ-溴丙炔基甲醇。
• 9-Allenyl-9-BBN: A new reagent for the efficient allenylboration of carbonyl compounds producing the homopropargylic alcohols in high purity and yield
  作者：Herbert C. Brown、Uday R. Khire、Uday S. Racherla

  DOI：10.1016/s0040-4039(00)60046-1

  日期：1993.1

  A new reagent, 9-allenyl-9-BBN (1), has been developed for the convenient and efficient synthesis of a variety of homopropargylic alcohols via the

  已经开发出一种新的试剂9-烯丙基-9-BBN（1），该试剂可通过以下方法方便高效地合成多种均丙醇：
• Hydroalumination of terminal β-acetylene alcohols with lithium aluminum hydride
  作者：O. A. Garibyan、G. M. Makaryan、M. R. Ogannisyan、Zh. A. Chobanyan

  DOI：10.1134/s1070363216020109

  日期：2016.2

  Hydrogenation of terminal β-acetylene alcohols with lithium aluminum hydride in THF has afforded homoallylic alcohols. Decomposition of the intermediate organoaluminum complex with deuterated water, iodine, or pyridinium dibromide has evidenced about the non-regioselective hydride attack at the triple bond.

  在THF中用氢化锂铝将末端β-乙炔醇加氢，得到均烯丙基醇。用氘化水，碘或二溴化吡啶分解中间有机铝配合物已证明在三键处非区域选择性氢化物的侵蚀。
• 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY
  申请人：Rieger Jayson M.

  公开号：US20090298788A1

  公开（公告）日：2009-12-03

  The invention provides compounds having the following general formula (I): wherein X, R 1 , R 2 , R 7 and Z are as described herein.

  本发明提供具有以下一般式(I)的化合物：其中X、R1、R2、R7和Z如本文所述。