1-[6-Chloro-2-(4-methylphenyl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one | 1263433-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-[6-Chloro-2-(4-methylphenyl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
• CAS: 1263433-08-4
• 化学式: C₂₀H₂₁ClN₂O
• 分子量: 340.853
• InChiKey: DDICRPMELFLVLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙烯基吡咯烷酮 、 p-chloro-N-(p-methylbenzylidene)aniline 在 phosphotungstic acid 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以80%的产率得到1-[6-Chloro-2-(4-methylphenyl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
  参考文献：
  名称：

  Phosphotungstic Acid: An Efficient Catalyst for Synthesis of 2-Substituted Tetrahydroquinoline via Imino Diels–Alder Reaction and Fluorescent Studies

  摘要：

  For the first time Phosphotungstic acid (PTA), is used as a some new catalyst for the synthesis of tetrahydroquinoline derivatives with high yields is described. PTA a heterogeneous catalyst is inexpensive, easily available, eco-friendly, water soluble, recoverable, stable to aqueous reaction conditions and further more, these 2-methyl tetrahydroquinoline derivatives shows a remarkable fluorescence property.

  DOI：

  10.1080/00397910903531672

文献信息

• Phosphotungstic Acid: An Efficient Catalyst for Synthesis of 2-Substituted Tetrahydroquinoline via Imino Diels–Alder Reaction and Fluorescent Studies
  作者：Kavitha C. S. Achar、Kallappa M. Hosamani、Harisha R. Seetharamareddy

  DOI：10.1080/00397910903531672

  日期：2010.12.21

  For the first time Phosphotungstic acid (PTA), is used as a some new catalyst for the synthesis of tetrahydroquinoline derivatives with high yields is described. PTA a heterogeneous catalyst is inexpensive, easily available, eco-friendly, water soluble, recoverable, stable to aqueous reaction conditions and further more, these 2-methyl tetrahydroquinoline derivatives shows a remarkable fluorescence property.