(3S)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-N,N-diethylpent-4-enamide | 339046-86-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (3S)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-N,N-diethylpent-4-enamide
• CAS: 339046-86-5
• 化学式: C₁₆H₃₃NO₂Si
• 分子量: 299.529
• InChiKey: CRFMSVVFOYMORI-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.07
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3S)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-N,N-diethylpent-4-enamide 在 盐酸 、 sodium tetrahydroborate 、 正丁基锂 、 草酰氯 、 叠氮磷酸二苯酯 、 氢氟酸 、 4-甲基苯磺酸吡啶 、 双(三甲基硅烷基)氨基钾 、 二异丁基氢化铝 、 二甲基亚砜 、 三乙胺 、 二异丙胺 、 三苯基膦 、 lithium diisopropyl amide 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 正己烷 、 二氯甲烷 、 甲苯 、 乙腈 、 xylene 为溶剂， 反应 64.58h， 生成 2-[(2S,4R,5R)-5-ethenyl-2-[(6-methoxyquinolin-4-yl)methyl]piperidin-4-yl]ethanol
  参考文献：
  名称：

  奎宁的首次立体选择性全合成

  摘要：

  报道了第一个完全立体选择性的 (-)-奎宁全合成。

  DOI：

  10.1021/ja004325r
• 作为产物：
  描述：

  (S)-4-乙烯基-二氢呋喃-2(3H)-酮 在 咪唑 、 4-二甲氨基吡啶 、 三甲基铝 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 (3S)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]-N,N-diethylpent-4-enamide
  参考文献：
  名称：

  奎宁的首次立体选择性全合成

  摘要：

  报道了第一个完全立体选择性的 (-)-奎宁全合成。

  DOI：

  10.1021/ja004325r

文献信息

• Unification of Reaction Metrics for Green Chemistry:  Applications to Reaction Analysis
  作者：John Andraos

  DOI：10.1021/op049803n

  日期：2005.3.1

  A formalism is presented which unifies key reaction metrics associated with "greenness" in chemical reactions with respect to raw materials usage. The fundamental basis of this treatment begins with balanced chemical reactions in which byproducts are identified. The primary or kernel metrics are reaction yield, scale of reaction, stoichiometric factor (SF), and Trost's atom economy (AE). The stoichiometric factor is a new metric that is defined to account for reactions run under nonstoichiometric conditions, that is, with one or more reagents in excess. A general relation for reaction mass efficiency (RME) is derived which shows that this metric is a composite of the aforementioned primary metrics and takes into account solvent usage in the reaction and postreaction phases (workup and purification). The Sheldon environmental impact factor E is treated at various levels of complexity according to what is constituted as waste and is shown to be related to RME by a simple inverse expression. A flowchart is presented which shows other simple relationships connecting all metrics. Raw material costs, optimum conditions for recycling or reclaiming catalysts and reaction and postreaction solvents, and the handling of reactions giving isomeric products are also assessed. General algorithms are proposed for determining kernel reaction metrics for linear and convergent sequences that can be used to compare the intrinsic, or best-case scenario, green performances of synthetic plans to a common target structure. All key relationships can be implemented in a spreadsheet format from which reaction histograms or "maps" can be generated. Individual reaction RME performances can be gauged, ranked, and decomposed according to AE, SF, and reaction yield kernel metrics. This allows for the easy identification of best and worst reactions in a process or sequence. Example applications of the present methodology include the following: (a) a comparative analysis of the synthesis of quinine by the classic Woodward-Rabe and the modern greener Stork methods; (b) the analysis of the industrial synthesis of sildenafil (Viagra) by a convergent strategy; and (c) the analysis of kinetic resolution of racemic alcohols by a successive oxidation and recycling reduction cycle.
• The First Stereoselective Total Synthesis of Quinine
  作者：Gilbert Stork、Deqiang Niu、A. Fujimoto、Emil R. Koft、James M. Balkovec、James R. Tata、Gregory R. Dake

  DOI：10.1021/ja004325r

  日期：2001.4.1

  The first entirely stereoselective total synthesis of (-)-quinine is reported.

  报道了第一个完全立体选择性的 (-)-奎宁全合成。