4-benzooxazol-2-yl-benzylamine | 760111-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-benzooxazol-2-yl-benzylamine
• 英文别名: [4-(1,3-benzoxazol-2-yl)phenyl]methanamine
• CAS: 760111-76-0
• 化学式: C₁₄H₁₂N₂O
• mdl: MFCD05240586
• 分子量: 224.262
• InChiKey: XTFNBGUXOKGTDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-benzooxazol-2-yl-benzylamine 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  New chelating ligands for Co(III)-based peptide-cleaving catalysts selective for pathogenic proteins of amyloidoses

  摘要：

  The Co(III) complex of 1,4,7,10-tetraazacyclododecane has been employed as the catalytic center of target-selective peptide-cleaving catalysts in previous studies. As new chelating ligands for the Co(III) ion in the peptide-cleaving catalysts, 1-oxo-4,7,10-triazacyclodedecane, 1-aryl-1,4,7,10-tetraazacyclodecane, and 7-aryl-1-oxo-4,7,10-triazacyclodecane were examined in the present study. A chemical library comprising 612 derivatives of the Co(III) complex of the new chelating ligands was constructed. The catalyst candidates were tested for their activity to cleave the soluble oligomers of amyloidogenic peptides amyloid beta-42 and human islet amyloid polypeptide (h-IAPP), which are believed to be the pathogenic species for Alzheimer's disease and type 2 diabetes mellitus, respectively. One derivative of the Co(III) complex of 1-aryl-1,4,7,10-tetraazacyclodecane was found to cleave the oligomers of h-IAPP. Cleavage products were identified and cleavage yields were measured at various catalyst concentrations for the action of the new catalyst. The present results reveal that effective catalytic drugs for amyloidoses may be obtained by using Co(III) complexes of various chelating ligands.

  DOI：

  10.1007/s00775-010-0750-y
• 作为产物：
  描述：

  methyl 4-((1,3-dioxoisoindolin-2-yl)methyl)benzoate 在 PPA 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 4-benzooxazol-2-yl-benzylamine
  参考文献：
  名称：

  抗菌剂。2.取代的苯并噻唑基苄胺和相关化合物。

  摘要：

  DOI：

  10.1021/jm00294a025

文献信息

• [EN] CYCLOPENTANECARBOXAMIDE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE<br/>[FR] DÉRIVÉS DE CYCLOPENTANECARBOXAMIDE, MÉDICAMENTS CONTENANT CES COMPOSÉS ET LEUR UTILISATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2011048018A1

  公开（公告）日：2011-04-28

  The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions containing them, wherein R1, R2, R3, LO, W, AR1, n are as defined in claim 1.

  这项发明涉及公式1的环戊烷羧酰胺衍生物，它们的用途是作为脂肪酸合成酶抑制剂，用于它们的治疗用途的方法，以及含有它们的药物组合物，其中R1、R2、R3、LO、W、AR1、n如权利要求1中所定义。
• CLEAVAGE AGENT SELECTIVELY ACTING ON SOLUBLE ASSEMBLY OF AMYLOIDOGENIC PEPTIDE OR PROTEIN
  申请人：Suh Jung Hun

  公开号：US20100036122A1

  公开（公告）日：2010-02-11

  The present invention relates to a cleavage agent and a cleavage method selectively acting on soluble assembly of amyloidogenic peptide or protein.

  这项发明涉及一种裂解剂和一种选择性作用于可溶性淀粉样肽或蛋白质组装体的裂解方法。
• Cyclopentanecarboxamide derivatives, medicaments containing such compounds and their use
  申请人：Kley Joerg

  公开号：US20130053412A1

  公开（公告）日：2013-02-28

  The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions containing them, wherein R 1 , R 2 , R 3 , LO, W, AR 1 , n are as defined in claim 1 .

  本发明涉及公式1的环戊烷羧酰胺衍生物，以及它们作为脂肪酸合成酶抑制剂的用途，它们的治疗应用方法以及含有它们的制药组合物，其中R1，R2，R3，LO，W，AR1，n如权利要求1所定义。
• NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME
  申请人：Industry-Academic Cooperation Foundation Yonsei University

  公开号：EP3431472A2

  公开（公告）日：2019-01-23

  The present invention relates to a novel compounds for inhibiting nicotinamide phosphoribosyltransferase (NamPT), a composition comprising the same, and various uses thereof.

  本发明涉及一种用于抑制烟酰胺磷酸核糖转移酶（NamPT）的新型化合物、包含该化合物的组合物及其各种用途。
• Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same
  申请人：CHECKMATE THERAPEUTICS INC.

  公开号：US11078195B2

  公开（公告）日：2021-08-03

  The present invention relates to a novel compounds for inhibiting nicotinamide phosphoribosyltransferase (NamPT), a composition comprising the same, and various uses thereof.

  本发明涉及一种用于抑制烟酰胺磷酸核糖转移酶（NamPT）的新型化合物、包含该化合物的组合物及其各种用途。