(E)-3-[4-(2-methylprop-2-enoxy)phenyl]prop-2-enoic acid | 1344724-42-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-[4-(2-methylprop-2-enoxy)phenyl]prop-2-enoic acid
• CAS: 1344724-42-0
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.252
• InChiKey: RTNWHFRPXNZLET-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-3-[4-(2-methylprop-2-enoxy)phenyl]prop-2-enoic acid 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-3-(4-((2-methylallyl)oxy)phenyl)-N-(5-phenyl-4H-1,2,4-triazol-3-yl)acrylamide
  参考文献：
  名称：

  Synthesis and preliminary biological evaluation of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives as potential antimycobacterial agents: An operational Topliss Tree approach

  摘要：

  A series of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives were designed on basis of structural similarity to the known FAS II inhibitors. Topliss operational method was used to optimize the potency of molecules. The minimum inhibitory concentration (MIC) of all synthesized compounds was determined against Mycobacterium tuberculosis H(37)R(v) using resazurin microtitre assay (REMA) plate method. The synthesized compounds exhibit antimycobacterial activity in the range of 5-95 mu M with a good safety profile. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.076

文献信息

• Organosilicon compounds their preparation and use
  申请人：GIVAUDAN-ROURE (INTERNATIONAL) S.A.

  公开号：EP0305059A2

  公开（公告）日：1989-03-01

  Organosilicon compounds having at least one unit of the general formula in which R represents alkyl, R′ is a divalent alkylene, oxyalkylene, alkenylene or oxyalkenylene, Z represents an alkyl, alkoxy or hydroxyl group, a has a value of 0, 1, 2 or 3 and c is 0 or 1, wherein at least one of Z and R′ is linked to the multi­valent aryl group via an ether linkage, are useful for absorbing UV radiation. Especially if polymeric (with e.g. diorganosi­loxane units) they can be incorporated in sunscreen preparations to improve their substantivity to the skin. A process for preparing the compounds is also disclosed.

  具有至少一个通式单元的有机硅化合物 其中 R 代表烷基，R′是二价亚烷基、氧烷基、烯基或氧烯基，Z 代表烷基、烷氧基或羟基，a 的值为 0、1、2 或 3，c 为 0 或 1，其中 Z 和 R′中至少有一个通过醚键与多价芳基相连。尤其是聚合型化合物（如二芳基硅氧烷单元），可以加入防晒制剂中以提高其对皮肤的吸附性。此外，还公开了制备这些化合物的工艺。
• Methods and reagents for the treatment of metabolic disorders
  申请人：Lee S. Margaret

  公开号：US20060069161A1

  公开（公告）日：2006-03-30

  The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.

  本发明的特点是用于治疗糖尿病和肥胖症等代谢性疾病的组合物、方法和试剂盒。
• US4026896A
  申请人：——

  公开号：US4026896A

  公开（公告）日：1977-05-31
• US4912241A
  申请人：——

  公开号：US4912241A

  公开（公告）日：1990-03-27
• US5077422A
  申请人：——

  公开号：US5077422A

  公开（公告）日：1991-12-31