2-nitro-2-nitroso-1,3-diphenyl-propane | 288853-73-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-nitro-2-nitroso-1,3-diphenyl-propane
• 英文别名: 2-Nitro-2-nitroso-1,3-diphenyl-propan；(2-Nitro-2-nitroso-3-phenylpropyl)benzene
• CAS: 288853-73-6
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: RBVWIPQDLVTADV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙醇 、 2-nitro-2-nitroso-1,3-diphenyl-propane 生成 2,2-dinitro-1,3-diphenyl-propane
  参考文献：
  名称：

  Charlton et al., Journal of the Chemical Society, 1932, p. 30,39

  摘要：

  DOI：
• 作为产物：
  描述：

  二苄醚 在 乙醚 、 dinitrogen tetraoxide 作用下， 生成 2-nitro-2-nitroso-1,3-diphenyl-propane
  参考文献：
  名称：

  Rheinboldt; Dewald, Chemische Berichte, 1927, vol. 60, p. 250

  摘要：

  DOI：

文献信息

• Pseudonitroles and Their Dimeric Azodioxides
  作者：Klaus Rehse、Martin Herpel

  DOI：10.1002/(sici)1521-4184(199802)331:2<79::aid-ardp79>3.0.co;2-9

  日期：1998.2

  Thirteen geminally substituted nitro-nitroso compounds (pseudonitroles) have been synthesized, four of them for the first time. In the solid state the pseudonitroles are dimerized to azo-dioxides. This is proved by IR spectroscopy, with the dimeric N-O valence vibration being observed between 1293 and 1306 cm(-1). Only 1,3-diphenyl-2-nitro-2-nitrosopropane is monomeric even when solid. This is backed by its blue color and an IR band at 1574 cm(-1). When dissolved in chloroform these azodioxides dissociate completely to the blue monomers (lambda(max) similar to 650 nm). Eight pseudonitroles inhibited the aggregation of blood platelets half-maximally at concentrations below 10 mu M (Born test, collagen). When administered orally to rats (60 mg/kg) the thrombus formation in mesenteric arterioles and venules was inhibited up to 25 percent (k: 1-nitro-1-nitrosocyclohexane). When kept in aqueous media at 37 degrees C nitric oxide and its reduced form, i.e. nitrosohydrogen, are released. This suggests that the above biological effects arise from an NO dependent mechanism. The lack of influence on the blood pressure of spontaneously hypertensive rats, however, strongly suggests that an enzyme supported rather than a thermal formation of NO occurs in vivo.
• Brauns bei Rheinboldt; Dewald, Chemische Berichte, 1927, vol. 60, p. 250
  作者：Brauns bei Rheinboldt、Dewald

  DOI：——

  日期：——
• Rheinboldt; Dewald, Chemische Berichte, 1927, vol. 60, p. 250
  作者：Rheinboldt、Dewald

  DOI：——

  日期：——
• Charlton et al., Journal of the Chemical Society, 1932, p. 30,39
  作者：Charlton et al.

  DOI：——

  日期：——