aspartic acid anion II | 63-71-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: aspartic acid anion II
• 英文别名: aspartate dianion；L-aspartate；aspartate；Asp^2-；Asp；L-aspartic acid; bis-deprotonated form；(2S)-2-aminobutanedioate
• CAS: 63-71-8
• 化学式: C₄H₅NO₄
• 分子量: 131.088
• InChiKey: CKLJMWTZIZZHCS-REOHCLBHSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  aspartic acid anion II 在 盐酸 、 sodium perchlorate 作用下， 生成 aspartate anion
  参考文献：
  名称：

  A thermodynamic insight into the recognition of hydrophilic and hydrophobic amino acids in pure water by aza-scorpiand type receptors

  摘要：

  在水中关于蝎烯和氮杂大环与氨基酸相互作用的热力学研究表明，熵驱动的稳定化通常与溶解/脱溶过程相关。

  DOI：

  10.1039/c4ob02092h
• 作为产物：
  描述：

  、 L-丝氨酸 、 L-精氨酸 、 L-异亮氨酸 、 L-亮氨酸 生成 L-丙氨酸 、 aspartic acid anion II 、 L-谷氨酸 、 L-色氨酸
  参考文献：
  名称：

  Assessment method

  摘要：

  一种评估细胞生存能力的方法包括将细胞孵育在培养基中。该培养基包括多种氨基酸，并确定至少一种氨基酸在培养基中的浓度变化。

  公开号：

  US07202395B2
• 作为试剂：
  描述：

  2-氧代戊烷-1,5-二甲酸二乙酯 在 cliona varians 、 aspartic acid anion II 作用下， 以 水 为溶剂， 反应 120.0h， 生成 (S)-2-羟基戊二酸二乙酯 、 (–)-(R)-diethyl 2-hydroxyglutarate
  参考文献：
  名称：

  Biotechnological Properties of Sponges from Northeast Brazil: Cliona varians as a Biocatalyst for Enantioselective Reduction of Carbonyl Compounds

  摘要：

  To research the potential ability of whole marine sponges to act as biocatalysts, this paper describes for the first time the employment of whole Cliona varians sponge in the stereoselective reduction of prochiral alpha-keto esters and isatin to the corresponding chiral alcohols. The addition of D-fructose, D-glucose or sucrose remarkably increased the conversion ratios and stereoselectivities by this marine sponge. Furthermore, in the presence of D-glucose and D-maltose. the reduction of isatin by C. varians afforded the corresponding 3-hydroxyindolin-2-one with high conversions (85-90%) and good enantioselectivities (60-74%). These results showed that the marine sponge presents great potential to be used as biocatalyst for stereoselective reduction of carbonyl compounds.

  DOI：

  10.21577/0103-5053.20180165

文献信息

• Purification and Characterization of the First Archaeal Glutamate Decarboxylase from<i>Pyrococcus horikoshii</i>
  作者：Han-Woo KIM、Yasuhiro KASHIMA、Kazuhiko ISHIKAWA、Naoko YAMANO

  DOI：10.1271/bbb.80583

  日期：2009.1.23

  Glutamate decarboxylase (GAD) from the archaeon Pyrococcus horikoshii was successfully expressed and purified, with the aim of developing a hyperthermostable GAD for industrial applications. Its biochemical properties were different from those reported for other GADs. The enzyme had broad substrate specificity, and its optimum pH and temperature were pH 8.0 and >97 °C.

  来自古菌株Pyrococcus horikoshii的谷氨酸脱羧酶(GAD)成功表达并纯化，旨在开发用于工业应用的超热稳定GAD。其生化特性与之前报道的其他GAD不同。该酶具有广泛的底物特异性，其最适pH和温度分别为pH 8.0和>97 °C。
• A Cooperative <i>Escherichia coli</i> Aspartate Transcarbamoylase without Regulatory Subunits,
  作者：Kimberly R. Mendes、Evan R. Kantrowitz

  DOI：10.1021/bi1010333

  日期：2010.9.7

  nucleotide-binding regulatory dimers, r2. By introducing specific disulfide bonds linking the catalytic chains from the upper trimer site specifically to their corresponding chains in the lower trimer prior to dissociation, a new catalytic unit, c6, was isolated consisting of two catalytic trimers linked by disulfide bonds. Not only does the c6 species display enhanced enzymatic activity compared to the wild-type

  在这里，我们报告了无调节亚基的协作大肠杆菌天冬氨酸氨基甲酰化酶 (ATCase)的分离、动力学表征和 X 射线结构测定。天然 ATCase 全酶由 6 条催化链组成，它们被组织成两个三聚体，由 6 个调节链非共价桥接，它们被组织成三个二聚体，c 6 r 6。天然全酶的解离产生具有催化活性的三聚体 c 3和核苷酸结合调节二聚体 r 2。通过引入特定的二硫键，在解离之前将催化链从上部三聚体位点连接到它们在下部三聚体中的相应链，一个新的催化单元，c 6, 由二硫键连接的两个催化三聚体组成。与野生型酶相比，不仅 c 6物种显示出增强的酶活性，而且二硫键还赋予同向协同性，这在野生型 c 3 中从未观察到。c 6 ATCase 在磷酸盐存在下结晶，其 X 射线结构确定为 2.10 Å 分辨率。c 6的结构与磷酸盐配体的 ATCase 以与其他 R 状态结构几乎相同的构象存在，具有相似的垂直间隔和平面角
• Method of effecting increased performance of diagnostic enzyme reaction
  申请人：American Air Liquide

  公开号：US05382525A1

  公开（公告）日：1995-01-17

  A method of effecting increased performance of diagnostic enzyme reaction systems which includes contacting at least one reagent of an enzyme-diagnostic kit during use of the reagent in conjuction with the kit with a noble gas, mixture of noble gases or gas mixtures containing at least one noble gas.

  一种提高诊断酶反应系统性能的方法，包括在使用酶诊断试剂盒的试剂时，将至少一种试剂与惰性气体、惰性气体混合物或至少含有一种惰性气体的气体混合物接触。
• Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines
  申请人：Warner-Lambert Company

  公开号：US05177217A1

  公开（公告）日：1993-01-05

  A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7-position is occupied with a sterospecific 3-amino-pyrrolidine side chain is described starting from inexpensive L-aspartic acid. L-aspartic acid is converted to the desired (S)-3-aminopyrrolidine via a novel, high yield transformation of a substituted aziridine.

  一种新的制备立体特异性(S)-3-氨基-1-取代吡咯烷的方法被描述，该化合物是制备喹诺酮和萘啶酮抗菌剂中7位被立体特异性3-氨基吡咯烷侧链占据的关键中间体。该方法从廉价的L-天冬氨酸开始，经过一种新颖的高产率取代环氮化合物转化，将L-天冬氨酸转化为所需的(S)-3-氨基吡咯烷。
• Eliminating turbidity in serum undergoing photometric assay
  申请人：Boehringer Mannheim GmbH

  公开号：US04184848A1

  公开（公告）日：1980-01-22

  An agent for the elimination of turbidity in serum, especially in serum samples wherein photometric measurements are to be made, consisting essentially of one or more mono- or di-esters of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said esters having an HLB value of from 8 to 12.8.

  一种用于消除血清混浊度的试剂，特别适用于需要进行光度测量的血清样本，其基本成分为聚乙二醇和9至14个碳原子的脂肪酸的单酯或二酯，每个脂肪酸部分子分子中最多含有8个乙氧基单元，所述酯的HLB值为8至12.8。