(S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine | 198410-25-2
中文名称
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中文别名
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英文名称
(S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine
英文别名
(S)-benzyl 4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazine-1-carboxylate；benzyl 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenyl]piperazine-1-carboxylate
CAS
198410-25-2
化学式
C22H25FN4O4
mdl
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分子量
428.463
InChiKey
GWIKZSISGJXSCV-SFHVURJKSA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
计算性质
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辛醇/水分配系数(LogP)：2
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重原子数：31
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可旋转键数：6
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环数：4.0
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sp3杂化的碳原子比例：0.36
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拓扑面积：88.3
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氢给体数：1
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氢受体数：7
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methyl azide 239438-48-3 C22H23FN6O4 454.461 —— (S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 174649-06-0 C24H27FN4O5 470.501 —— (R)-[N-3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]methanol 174649-04-8 C22H24FN3O5 429.448 —— benzyl 4-[2-fluoro-4-[(5R)-5-(methylsulfonyloxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate 903594-02-5 C23H26FN3O7S 507.54 —— 4-{4-[Benzyloxycarbonyl-((S)-2,3-dihydroxy-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 912552-59-1 C29H32FN3O6 537.588 —— 4-{4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 912552-57-9 C29H32FN3O5 521.589 —— 4-{4-[Benzyloxycarbonyl-(3-oxo-propyl)-amino]-2-fluoro-phenyl}-piperazine-1-carboxylic acid benzyl ester 912552-58-0 C29H30FN3O5 519.573 —— N-[[(5S)-3-[3-fluoro-4-[4-(2-phenylmethoxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide 174649-08-2 C25H29FN4O5 484.527 N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷基]甲基]-乙酰胺 eperezolid 165800-04-4 C18H23FN4O5 394.403 (S)-N-((3-(3-氟-4-(哌嗪-1-基)苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 154590-66-6 C16H21FN4O3 336.366 —— (S)-N-[[3-[3-fluoro-4-[4-carbobenzoxypiperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide 174649-05-9 C30H27FN4O6 558.566 —— (R)-benzyl 4-(2-fluoro-4-(2-oxo-5-(tosyloxymethyl)oxazolidin-3-yl)phenyl)piperazine-1-carboxylate 1281885-30-0 C29H30FN3O7S 583.638 —— N-carbobenzoxy-3-fluoro-4-(N-carbobenzoxypiperazin-1-yl)aniline 174649-03-7 C26H26FN3O4 463.509 —— benzyl 4-[2-fluoro-4-[(5R)-5-[(3-nitrophenyl)sulfonyloxymethyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate —— C28H27FN4O9S 614.608 4-(4-Boc-哌嗪-1-基)-3-氟苯胺 tert-butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 154590-35-9 C15H22FN3O2 295.357 4-(2-氟-4-硝基苯基)哌嗪-1-羧酸叔丁酯 4-(2-fluoro-4-nitrophenyl)-piperazine-1-carboxylic acid tert butyl ester 154590-34-8 C15H20FN3O4 325.34 - 1
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 174649-06-0 C24H27FN4O5 470.501 —— benzyl 4-[2-fluoro-4-[(5S)-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperazine-1-carboxylate 273376-94-6 C27H33FN4O6 528.581 —— N-[[(5S)-3-[3-fluoro-4-[4-(2-phenylmethoxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide 174649-08-2 C25H29FN4O5 484.527 N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷基]甲基]-乙酰胺 eperezolid 165800-04-4 C18H23FN4O5 394.403 (S)-N-((3-(3-氟-4-(哌嗪-1-基)苯基)-2-氧代噁唑啉-5-基)甲基)乙酰胺 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 154590-66-6 C16H21FN4O3 336.366 —— (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-methyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione 1280555-50-1 C30H31FN6O6S 622.677 —— (S)-N-((3-(3-fluoro-4-(4-(3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yloxy)propyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide hydrochloride 1282094-22-7 C26H32BFN4O6 526.373 —— (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione 1280555-51-2 C31H33FN6O6S 636.704 —— (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-phenyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione 1280555-52-3 C35H33FN6O6S 684.748 —— (5S)-3-(3-fluoro-4-piperazin-1-ylphenyl)-5-[[(4-methyl-1,1-dioxo-1lambda6,2,4-benzothiadiazin-3-ylidene)amino]methyl]-1,3-oxazolidin-2-one 1280555-54-5 C22H25FN6O4S 488.543 —— (S)-[{N-3-[3-fluoro-4-(4-(4-methyl-1,1-dioxo-1,4-dihydro-1,2,4-benzothiadiazin-3-yl)piperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]acetamide 1280555-44-3 C24H27FN6O5S 530.58 —— (5S)-5-[[(4-ethyl-1,1-dioxo-1lambda6,2,4-benzothiadiazin-3-ylidene)amino]methyl]-3-(3-fluoro-4-piperazin-1-ylphenyl)-1,3-oxazolidin-2-one 1280555-57-8 C23H27FN6O4S 502.57 —— (S)-[{N-3-[3-fluoro-4-(4-(4-ethyl-1,1-dioxo-1,4-dihydro-1,2,4-benzothiadiazin-3-yl)piperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]acetamide 1280555-46-5 C25H29FN6O5S 544.607 —— (5S)-5-[[(1,1-dioxo-4-phenyl-1lambda6,2,4-benzothiadiazin-3-ylidene)amino]methyl]-3-(3-fluoro-4-piperazin-1-ylphenyl)-1,3-oxazolidin-2-one 1280555-59-0 C27H27FN6O4S 550.614 —— (S)-[{N-3-[3-fluoro-4-(4-(4-phenyl-1,1-dioxo-1,4-dihydro-1,2,4-benzothiadiazin-3-yl)piperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]acetamide 1280555-49-8 C29H29FN6O5S 592.651 - 1
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反应信息
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作为反应物：描述：(S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine 在 palladium on activated charcoal 吡啶 、 二氯甲烷 、 氢气 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 4.5h， 生成 N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷