Syntheses of Pyrroles, Pyridines, and Ketonitriles via Catalytic Carbopalladation of Dinitriles
作者:Linjun Qi、Renhao Li、Xinrong Yao、Qianqian Zhen、Pengqing Ye、Yinlin Shao、Jiuxi Chen
DOI:10.1021/acs.joc.9b02999
日期:2020.1.17
The first example of the Pd-catalyzed addition of organoboron reagents to dinitriles, as an efficient means of preparing 2,5-diarylpyrroles and 2,6-diarylpyridines, has been discussed here. Furthermore, the highly selective carbopalladation of dinitriles with organoboron reagents to give long-chain ketonitriles has been developed as well. Based on the broad scope of substrates, excellent functional
本文讨论了Pd催化向二腈中添加有机硼试剂的第一个例子,这是制备2,5-二芳基吡咯和2,6-二芳基吡啶的有效方法。此外,还开发了用有机硼试剂对二腈进行高度选择性的碳巴巴定反应以生成长链酮腈。基于底物的广泛范围,优异的官能团耐受性和可商购的底物的使用,预期芳基硼酸和二腈的Pd催化加成反应在未来的合成方法中将是重要的。