5-(2-Bromoethoxy)-2-(3,4-diethoxyphenyl)-3,7-diethoxychromen-4-one | 82547-05-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-(2-Bromoethoxy)-2-(3,4-diethoxyphenyl)-3,7-diethoxychromen-4-one
• CAS: 82547-05-5
• 化学式: C₂₅H₂₉BrO₇
• 分子量: 521.405
• InChiKey: BUVGJRQCCUZTTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(2-Bromoethoxy)-2-(3,4-diethoxyphenyl)-3,7-diethoxychromen-4-one 、 二乙胺 以 苯 为溶剂， 反应 4.0h， 以50%的产率得到5-<(diethylamino)ethyl>-3,3',4',7-tetra-O-ethylquercetin hydrochloride
  参考文献：
  名称：

  Pentasubstituted quercetin analogs as selective inhibitors of particulate 3',5'-cyclic-AMP phosphodiesterase from rat brain

  摘要：

  Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis. They inhibit more potently the particulate enzyme than the cytosolic preparation. The highest selectivity was observed with penta-O-ethylquercetin and analogue 6d, which proved to be more selective and more potent inhibitors than the reference compound Ro 20-1724. Some structure-activity relationships are discussed.

  DOI：

  10.1021/jm00352a019
• 作为产物：
  描述：

  槲皮素 、 alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 potassium carbonate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 41.0h， 生成 5-(2-Bromoethoxy)-2-(3,4-diethoxyphenyl)-3,7-diethoxychromen-4-one
  参考文献：
  名称：

  Pentasubstituted quercetin analogs as selective inhibitors of particulate 3',5'-cyclic-AMP phosphodiesterase from rat brain

  摘要：

  Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis. They inhibit more potently the particulate enzyme than the cytosolic preparation. The highest selectivity was observed with penta-O-ethylquercetin and analogue 6d, which proved to be more selective and more potent inhibitors than the reference compound Ro 20-1724. Some structure-activity relationships are discussed.

  DOI：

  10.1021/jm00352a019

文献信息

• Pentasubstituted quercetin analogs as selective inhibitors of particulate 3',5'-cyclic-AMP phosphodiesterase from rat brain
  作者：Madeleine Picq、Annie F. Prigent、Georges Nemoz、Annie C. Andre、Henri Pacheco

  DOI：10.1021/jm00352a019

  日期：1982.10

  Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis. They inhibit more potently the particulate enzyme than the cytosolic preparation. The highest selectivity was observed with penta-O-ethylquercetin and analogue 6d, which proved to be more selective and more potent inhibitors than the reference compound Ro 20-1724. Some structure-activity relationships are discussed.