5-methylsulfanyl-pentan-2-one | 89534-22-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-methylsulfanyl-pentan-2-one
• 英文别名: 5-Methylmercapto-pentan-2-on；5-methylthio-2-pentanone；5-(Methylsulfanyl)pentan-2-one；5-methylsulfanylpentan-2-one
• CAS: 89534-22-5
• 化学式: C₆H₁₂OS
• 分子量: 132.227
• InChiKey: HCUNIMILPJJQES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methylsulfanyl-pentan-2-one 在 sodium periodate 作用下， 生成 5-methanesulfinyl-pentan-2-one
  参考文献：
  名称：

  Transannular Sulfoxide-Ketone Reactions and Oxygen Transfer

  摘要：

  DOI：

  10.1021/ja00878a022
• 作为产物：
  描述：

  5-溴-2-戊酮 在 sodium hydrogensulfide 、 乙醚 、 乙醇 作用下， 生成 5-methylsulfanyl-pentan-2-one
  参考文献：
  名称：

  Bacchetti; Fiecchi, Gazzetta Chimica Italiana, 1953, vol. 83, p. 1037,1038, 1041

  摘要：

  DOI：

文献信息

• CYTOTOXIC AGENTS COMPRISING NEW ANSAMITOCIN DERIVATIVES
  申请人：ImmunoGen, Inc.

  公开号：US20160058882A1

  公开（公告）日：2016-03-03

  New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

  披露了带有连接基团的新型安沙米托辛衍生物。还披露了合成这些新型安沙米托辛衍生物的方法以及它们与细胞结合剂的连接方法。安沙米托辛衍生物-细胞结合剂偶联物作为治疗剂非常有用，它们能特异性地传递到目标细胞并具有细胞毒性。与先前描述的药物相比，这些偶联物在动物肿瘤模型中显示出显著提高的治疗效果。
• NEUROMEDIN U DERIVATIVE
  申请人：Ohtaki Tetsuya

  公开号：US20100286035A1

  公开（公告）日：2010-11-11

  The objective of the present invention is to provide a new antifeedant. The other objective of the present invention is to provide a NMU derivative showing a high antifeedant activity even in common administration forms such as peripheral administration. A neuromedin U derivative wherein a methoxypolyethylene glycol is bound via a linker having a specific structure to a polypeptide which contains at least 8 amino acids of the C-terminus of an amino acid sequence of neuromedin U and which consists of the same or substantially the same amino acid sequence as the amino acid sequence of neuromedin U.

  本发明的目的是提供一种新的抗饲料剂。本发明的另一个目的是提供一种NMU衍生物，即使在常见的给药形式如周围给药中也表现出高抗饲料活性。一种神经介质U衍生物，其中通过具有特定结构的连接物将甲氧基聚乙二醇与包含神经介质U氨基酸序列C-末端至少8个氨基酸的多肽结合，该多肽由与神经介质U氨基酸序列相同或基本相同的氨基酸序列组成。
• CYTOTOXIC BENZODIAZEPINE DERIVATIVES
  申请人：IMMUNOGEN, INC.

  公开号：US20160082114A1

  公开（公告）日：2016-03-24

  The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

  该发明涉及具有抗增殖活性的新型苯二氮䓬类衍生物，更具体地涉及具有式(I)-(VI)的新型苯二氮䓬类化合物。该发明还提供了将苯二氮䓬类化合物与细胞结合剂连接的结合物。该发明还提供了使用该发明的化合物或结合物抑制异常细胞生长或治疗哺乳动物增生性疾病的有效组合物和方法。
• Fragrance Compositions Comprising Ionic Liquids
  申请人：The Procter & Gamble Company

  公开号：US20170121633A1

  公开（公告）日：2017-05-04

  The present invention relates to a fragrance composition comprising ionic liquids for delayed evaporation of the perfume raw materials. The invention also relates to methods of use of the fragrance compositions for perfuming suitable substrates, particularly skin and hair.

  本发明涉及一种香精组合物，包括离子液体，用于延迟香水原料的挥发。该发明还涉及使用香精组合物来香味适合的基质的方法，特别是皮肤和头发。
• Method and compounds for diagnosing coronary artery disease
  申请人：Gensia, Inc.

  公开号：US05775329A1

  公开（公告）日：1998-07-07

  The present invention relates generally to methods of diagnosis, evaluation and treatment of coronary artery disease in mammals using substituted catecholamines and compounds therefore. It also relates to the preparation, use and administration of these compounds which are useful in the diagnosis, evaluation and treatment of coronary artery disease by means of a feedback controlled drug delivery system that delivers exercise simulating agents which are capable of eliciting acute responses similar to those elicited by aerobic exercise.

  本发明通常涉及使用替代儿茶酚胺和相关化合物对哺乳动物进行冠状动脉疾病的诊断、评估和治疗的方法。它还涉及这些化合物的制备、使用和管理，这些化合物可通过反馈控制的药物输送系统在冠状动脉疾病的诊断、评估和治疗中发挥作用，该系统提供能够引发类似有氧运动引发的急性反应的运动模拟剂。