5-(4-氯苯基)-1-甲基-1H-咪唑-2-硫醇 | 17452-31-2

• 物质功能分类: 化学试剂 - 有机试剂 - 硫醇盐
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-(4-氯苯基)-1-甲基-1H-咪唑-2-硫醇
• 英文名称: 5-(chlorophenyl)-1-methyl-1H-imidazole-2-thiol
• 英文别名: 4-(p-Chlor-phenyl)-3-methyl-2-mercapto-imidazol；5-(4-chloro-phenyl)-1-methyl-1,3-dihydro-imidazole-2-thione；5-(4-chlorophenyl)-1-methyl-1H-imidazole-2-thiol；4-(4-chlorophenyl)-3-methyl-1H-imidazole-2-thione
• CAS: 17452-31-2
• 化学式: C₁₀H₉ClN₂S
• mdl: MFCD01313844
• 分子量: 224.714
• InChiKey: RGYNOPLNIDBIGT-UHFFFAOYSA-N

物化性质

• 熔点：
  244 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  47.4
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  1,1-二(羟甲基)环丁烷 、 5-(4-氯苯基)-1-甲基-1H-咪唑-2-硫醇 生成 [1-({[5-(4-chlorophenyl)-1-methyl-1H-imidazol-2-yl]sulfanyl}methyl)cyclobutyl]methanol
  参考文献：
  名称：

  Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors

  摘要：

  本文介绍了环状酰胺类酮衍生物，其作为卡他普星K抑制剂具有用途。所述发明还包括制备这种环状酰胺类酮衍生物的方法，以及使用它们治疗与增强骨转换相关的疾病（包括骨质疏松症），最终可导致骨折的方法。

  公开号：

  US20050054819A1

文献信息

• [EN] METHODS AND COMPOSITIONS TO MODIFY GSK-3 ACTIVITY<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR MODIFIER L'ACTIVITÉ DE GSK-3
  申请人：UNIV OHIO

  公开号：WO2016010611A1

  公开（公告）日：2016-01-21

  Methods for modulating GSK-3 activity and methods for treating a GSK-3 -mediated disorder in a subject in need thereof. The methods include contacting a cell expressing GSK-3 with or administering to the subject in need a therapeutically effective amount of one or more compounds of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof.

  调节GSK-3活性的方法和治疗需要的主体中GSK-3介导的疾病的方法。该方法包括将表达GSK-3的细胞与或向需要的主体施用一种或多种通用式(I)或通用式(II)的化合物的治疗有效量接触，或其药用接受的盐或溶剂。
• Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
  申请人：Catalano George John

  公开号：US20050054819A1

  公开（公告）日：2005-03-10

  Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

  本文介绍了环状酰胺类酮衍生物，其作为卡他普星K抑制剂具有用途。所述发明还包括制备这种环状酰胺类酮衍生物的方法，以及使用它们治疗与增强骨转换相关的疾病（包括骨质疏松症），最终可导致骨折的方法。
• CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS
  申请人：Catalano George John

  公开号：US20080058333A1

  公开（公告）日：2008-03-06

  Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

  本文描述了环状烷基酮酰胺衍生物，其作为猫hepsin K抑制剂具有用途。所述发明还包括制备这种环状烷基酮酰胺衍生物的方法，以及使用它们治疗与增强骨转换相关的疾病的方法，包括骨质疏松症，最终可能导致骨折。
• 1,4-Dihydropyridine-Fused Heterocycles, Process for Preparing the Same, Use and Compositions Containing Them
  申请人：MAUGER Jacques

  公开号：US20080261969A1

  公开（公告）日：2008-10-23

  This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.

  本发明涉及式(I)化合物、制备该类化合物的方法、包含该类化合物的药物组合物，以及通过给予该类化合物的治疗方法。
• Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
  申请人：SmithKline Beecham Corporation

  公开号：US07282512B2

  公开（公告）日：2007-10-16

  Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

  本文描述了用作cathepsin K抑制剂的环状酰胺衍生物。所述的发明还包括制备这种环状酰胺衍生物的方法，以及在治疗与增强骨转换有关的疾病，包括骨质疏松症，最终可能导致骨折的方法。