2-methyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid | 207556-13-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-methyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid
• 英文别名: 2-Methyl-3-(2,4,5-trimethoxy-phenyl)-acrylsaeure；2.4.5-Trimethoxy-α-methyl-zimtsaeure；α-methyl-2,4,5-trimethoxycinnamic acid；2-Methyl-3-(2,4,5-trimethoxyphenyl)prop-2-enoic acid
• CAS: 207556-13-6
• 化学式: C₁₃H₁₆O₅
• mdl: MFCD00134074
• 分子量: 252.267
• InChiKey: CYOZQZKHPLWQCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-氨基苯基)-2-甲基丙酸 、 2-methyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid 生成
  参考文献：
  名称：

  FR2267764

  摘要：

  公开号：
• 作为产物：
  描述：

  1,2,4-三甲氧基苯 在 盐酸 、 三氯化铝 、 sodium proprionate 、 苯 作用下， 生成 2-methyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid
  参考文献：
  名称：

  Gattermann; Eggers, Chemische Berichte, 1899, vol. 32, p. 290

  摘要：

  DOI：

文献信息

• Colorant compounds
  申请人：Banning H. Jeffrey

  公开号：US20060020141A1

  公开（公告）日：2006-01-26

  Compounds of the formula wherein M is either (1) a metal ion having a positive charge of +y wherein y is an integer which is at least 2, said metal ion being capable of forming a compound with at least two chromogen moieties, or (2) a metal-containing moiety capable of forming a compound with at least two chromogen moieties, z is an integer representing the number of chromogen moieties associated with the metal and is at least 2, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , a, b, c, d, Y, and z are as defined herein, Q − is a COO − group or a SO 3 — group, A is an organic anion, and CA is either a hydrogen atom or a cation associated with all but one of the Q − groups.

  式中的化合物，其中M是一个带有正电荷+y的金属离子，其中y是至少为2的整数，该金属离子能够与至少两个色团基团形成化合物，或者M是一个含金属基团的基团，能够与至少两个色团基团形成化合物，z是表示与金属相关的色团基团数量的整数，至少为2，R1、R2、R3、R4、R5、R6、R7、a、b、c、d、Y和z的定义如上所述，Q-是一个COO-基团或SO3-基团，A是一个有机阴离子，CA是一个氢原子或与除一个Q-基团之外的所有Q-基团相关联的阳离子。
• [EN] INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES<br/>[FR] INHIBITEURS DE PROTÉINES TYROSINE PHOSPHATASES
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014055768A1

  公开（公告）日：2014-04-10

  Novel protein tyrosine phosphatase (PTP) inhibitor compounds synthesized from phosphonodifluoromethyl phenylalanine (F2Pmp) are provided. Use of these compounds for inhibiting a PTP enzyme (such as PTP-MEG2), as well as treating a disease, disorder, or condition associated with inappropriate activity of a PTP (such as type 2 diabetes), is also provided.

  提供了从磷酸二氟甲基苯丙氨酸（F2Pmp）合成的新型蛋白酪氨酸磷酸酶（PTP）抑制剂化合物。还提供了使用这些化合物来抑制PTP酶（如PTP-MEG2），以及治疗与PTP不当活性相关的疾病、紊乱或病况（如2型糖尿病）的方法。
• Oxazolidinone combinatorial libraries, compositions and methods of preparation
  申请人：Gordeev F. Mikhail

  公开号：US20050004174A1

  公开（公告）日：2005-01-06

  Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

  本发明提供了氧杂环丙烷酮及其合成方法。还提供了包含氧杂环丙烷酮的组合化学文库以及制备这些文库的方法。此外，还提供了制备生物活性氧杂环丙烷酮的方法以及包含氧杂环丙烷酮的药学可接受组合物的方法。文库制备的方法包括将氧杂环丙烷酮附着到固体支持上。在一种实施例中，化合物制备的方法涉及将亚胺磷酰胺与含有羰基的聚合物支持物反应。
• Process for preparing tetra-amide compounds
  申请人：Wu Bo

  公开号：US20050090690A1

  公开（公告）日：2005-04-28

  Disclosed is a process for preparing a tetra-amide which comprises carrying out a condensation reaction between a diacid, a monoacid, and a diisocyanate, thereby forming a tetra-amide. Also disclosed is a process for preparing a phase change ink composition which comprises (a) carrying out a condensation reaction between a diacid, a monoacid, and a diisocyanate, thereby forming a tetra-amide; and (b) admixing the tetra-amide thus formed with a colorant, thereby forming a phase change ink.

  本发明公开了一种制备四酰胺的方法，包括通过在二酸、单酸和二异氰酸酯之间进行缩合反应，从而形成四酰胺。本发明还公开了一种制备相变墨水组合物的方法，包括(a)通过在二酸、单酸和二异氰酸酯之间进行缩合反应，从而形成四酰胺；和(b)将形成的四酰胺与颜料混合，从而形成相变墨水。
• AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR
  申请人：SUNTORY LIMITED

  公开号：EP0755923A1

  公开（公告）日：1997-01-29

  A medicine having the following basic structure, for the alleviation or treatment of symptoms derived from ischemic diseases and seizures, epilepsy, and migraine, having a powerful action in suppressing cytotoxic Ca2+ overload and free from side-effects: wherein Z = C, CH, or N, X = O or CH2, E and Y = H, OH, a halogen, alkoxy, alkyl, or a halogen-substituted alkyl.

  一种具有以下基本结构的药物，用于缓解或治疗缺血性疾病和癫痫发作、癫痫和偏头痛引起的症状，在抑制细胞毒性 Ca2+ 过载方面具有强大的作用，且无副作用： 其中 Z = C、CH 或 N，X = O 或 CH2，E 和 Y = H、OH、卤素、烷氧基、烷基或卤素取代的烷基。