tert-butyl (2S,3S-)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-oxobutan-2-ylcarbamate | 1254059-87-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl (2S,3S-)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-oxobutan-2-ylcarbamate
• 英文别名: Tert-butyl (2S,3S)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-oxobutan-2-ylcarbamate；tert-butyl N-[(2S,3S)-3-[tert-butyl(dimethyl)silyl]oxy-4-oxo-1-prop-2-enoxybutan-2-yl]carbamate
• CAS: 1254059-87-4
• 化学式: C₁₈H₃₅NO₅Si
• 分子量: 373.565
• InChiKey: YMRFRRPBSXXKMG-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2-spirocyclobutyl-6-neopentyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-5-amine 、 tert-butyl (2S,3S-)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-oxobutan-2-ylcarbamate 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 tert-butyl (2S,3R)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-(2,2-spirocyclobutyl-6-neopentyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-5-ylamino)butan-2-ylcarbamate
  参考文献：
  名称：

  WO2007/61670

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl (2S,3S-)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-hydroxybutan-2-ylcarbamate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 tert-butyl (2S,3S-)-1-(allyloxy)-3-(tert-butyldimethylsilyloxy)-4-oxobutan-2-ylcarbamate
  参考文献：
  名称：

  WO2007/61670

  摘要：

  公开号：

文献信息

• Beta-secretase modulators and methods of use
  申请人：Zhong Wenge

  公开号：US20070185144A1

  公开（公告）日：2007-08-09

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R 3 , R 4 , R 5 , i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

  本发明涉及一类新型化合物，可用于调节β-分泌酶酶活性和治疗β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一种实施方式中，化合物具有通式I，其中A、B、W、R3、R4、R5、i和j在此定义。本发明还包括包含一个或多个通式I化合物的药物组合物，以及使用这些化合物的方法，包括通过将通式I化合物或包含它们的组合物给予受试者治疗AD和相关疾病。本发明还包括通式II和III的进一步实施方式，以及用于制备本发明化合物的中间体和过程。
• Beta-Secretase modulators and methods of use
  申请人：Amgen Inc.

  公开号：US07973047B2

  公开（公告）日：2011-07-05

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

  本发明涉及一类新的化合物，用于调节Beta-分泌酶酶活性和治疗Beta-分泌酶介导的疾病，包括阿尔茨海默氏病（AD）和相关疾病。在一种实施例中，所述化合物具有一般式I，其中A、B、W、R3、R4、R5、i和j在此定义。本发明还涉及包括一种或多种I式化合物的制药组合物，以及使用这些化合物的方法，包括通过将I式化合物或包含它们的组合物用于治疗AD和相关疾病来给予受试者。本发明还涉及进一步的II式和III式的实施例，以及制备本发明化合物的中间体和过程。
• BETA-SECRETASE MODULATORS AND METHODS OF USE
  申请人：Zhong Wenge

  公开号：US20100222338A1

  公开（公告）日：2010-09-02

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R 3 , R 4 , R 5 , i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

  本发明涉及一类新型化合物，可用于调节β-分泌酶酶活性和治疗β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一种实施例中，该化合物具有一般式I，其中A、B、W、R3、R4、R5、i和j在此被定义。本发明还包括包含一种或多种I式化合物的制药组合物，以及使用这些化合物的方法，包括通过将I式化合物或包含它们的组合物用于治疗AD和相关疾病来给受试者施用。本发明还包括进一步的II式和III式的实施例，以及用于制备本发明化合物的中间体和方法。
• WO2007/61670
  申请人：——

  公开号：——

  公开（公告）日：——