(4-nitrophenyl)(2,4,6-trihydroxyphenyl)methanone | 499973-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-nitrophenyl)(2,4,6-trihydroxyphenyl)methanone
• 英文别名: 2,4,6-trihydroxy-4'-nitro-benzophenone；2,4,6-Trihydroxy-4'-nitro-benzophenon；(4-Nitrophenyl)(2,4,6-trihydroxyphenyl)methanone；(4-nitrophenyl)-(2,4,6-trihydroxyphenyl)methanone
• CAS: 499973-16-9
• 化学式: C₁₃H₉NO₆
• 分子量: 275.218
• InChiKey: WAPRCJWSYNWLIW-UHFFFAOYSA-N

物化性质

• 熔点：
  244-245 °C
• 沸点：
  501.3±38.0 °C(Predicted)
• 密度：
  1.575±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4-nitrophenyl)(2,4,6-trihydroxyphenyl)methanone 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以100%的产率得到(4-Aminophenyl)-(2,4,6-trihydroxyphenyl)methanone
  参考文献：
  名称：

  Phloroglucinol based podands, versatile tripodal ligands

  摘要：

  The synthesis of four phloroglucinol based podands is described. Ligands 4 and 5 have three bipyridine arms and an induced octahedral cavity ideal for transition metal complexation. The iron(II) complex of 4 is described. Tripodes 6 and 7 possess three bipyridine-carboxylate arms, and are designed for the encapsulation of luminescent lanthanide salts. Some preliminary optical properties of the corresponding Eu3+ and Tb3+ are presented. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02213-x
• 作为产物：
  描述：

  间苯三酚 、 4-硝基苯甲酰氯 在 aluminum (III) chloride 作用下， 以 硝基苯 为溶剂， 反应 2.5h， 以36%的产率得到(4-nitrophenyl)(2,4,6-trihydroxyphenyl)methanone
  参考文献：
  名称：

  5,7-二羟基香豆素衍生物抗菌活性的合成与评价

  摘要：

  本研究考察了 5,7-二羟基香豆素衍生物的合成和抗菌活性，其结构已通过分析和光谱数据得到证实。研究了 20 种化合物对大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌和鼠伤寒沙门氏菌等五种微生物的抗菌活性。化合物 5 和 12 对金黄色葡萄球菌表现出最有效的活性，每种化合物的 MIC 值为 2.5 µg/mL。

  DOI：

  10.1002/ardp.201000233

文献信息

• Yamashita, Sci. Rep. Tohoku Univ., Ser. 1: Phys., Chem., Astron., 1929, vol. <I> 18, p. 609,612
  作者：Yamashita

  DOI：——

  日期：——
• [EN] FUNCTIONALISED BENZOPYRAN COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE BENZOPYRANE FONCTIONNALISÉS ET LEURS UTILISATIONS
  申请人：[en]NOXOPHARM LIMITED

  公开号：WO2023235929A1

  公开（公告）日：2023-12-14

  The present disclosure relates generally to compounds with anti-cancer and/or anti-fibrotic properties. In particularn the disclosure relates to functionalised benzopyran compounds, the preparation thereof, and their use.
• Synthesis and Evaluation of Antibacterial Activities of 5,7-Dihydroxycoumarin Derivatives
  作者：Yi-Ping Chin、Wei-Jan Huang、Feng-Lin Hsu、Yuh-Ling Lin、Mei-Hsiang Lin

  DOI：10.1002/ardp.201000233

  日期：2011.6

  examines the synthesis and antibacterial activities of 5,7‐dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus

  本研究考察了 5,7-二羟基香豆素衍生物的合成和抗菌活性，其结构已通过分析和光谱数据得到证实。研究了 20 种化合物对大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌和鼠伤寒沙门氏菌等五种微生物的抗菌活性。化合物 5 和 12 对金黄色葡萄球菌表现出最有效的活性，每种化合物的 MIC 值为 2.5 µg/mL。
• Phloroglucinol based podands, versatile tripodal ligands
  作者：Gilles Ulrich、Sébastien Bedel、Claude Picard

  DOI：10.1016/s0040-4039(02)02213-x

  日期：2002.12

  The synthesis of four phloroglucinol based podands is described. Ligands 4 and 5 have three bipyridine arms and an induced octahedral cavity ideal for transition metal complexation. The iron(II) complex of 4 is described. Tripodes 6 and 7 possess three bipyridine-carboxylate arms, and are designed for the encapsulation of luminescent lanthanide salts. Some preliminary optical properties of the corresponding Eu3+ and Tb3+ are presented. (C) 2002 Elsevier Science Ltd. All rights reserved.