1-(4-Hydroxy-3,5-diisopropyl-phenyl)-2-morpholin-4-yl-ethanone | 347381-91-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Hydroxy-3,5-diisopropyl-phenyl)-2-morpholin-4-yl-ethanone
• 英文别名: 1-[4-Hydroxy-3,5-di(propan-2-yl)phenyl]-2-morpholin-4-ylethanone；1-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-2-morpholin-4-ylethanone
• CAS: 347381-91-3
• 化学式: C₁₈H₂₇NO₃
• 分子量: 305.417
• InChiKey: PUJYWOKIRFDSFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-Hydroxy-3,5-diisopropyl-phenyl)-2-morpholin-4-yl-ethanone 在 氢氧化钾 、 lithium aluminium tetrahydride 、 钾硼氢 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 4-(2-Morpholin-4-ylethyl)-2,6-di(propan-2-yl)phenol
  参考文献：
  名称：

  Water-soluble propofol analogues with intravenous anaesthetic activity

  摘要：

  Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00088-9
• 作为产物：
  描述：

  丙泊酚 在 三氯化铝 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4-Hydroxy-3,5-diisopropyl-phenyl)-2-morpholin-4-yl-ethanone
  参考文献：
  名称：

  Water-soluble propofol analogues with intravenous anaesthetic activity

  摘要：

  Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00088-9

文献信息

• Water-soluble propofol analogues with intravenous anaesthetic activity
  作者：Andrew Cooke、Alison Anderson、Kirsteen Buchanan、Alan Byford、David Gemmell、Niall Hamilton、Petula McPhail、Susan Miller、Hardy Sundaram、Peter Vijn

  DOI：10.1016/s0960-894x(01)00088-9

  日期：2001.4

  Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. (C) 2001 Elsevier Science Ltd. All rights reserved.