2-methoxy-3-methyl-6-β-D-xylofuranosylaminopyrimidin-4-(3H)-one | 160053-36-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methoxy-3-methyl-6-β-D-xylofuranosylaminopyrimidin-4-(3H)-one
• 英文别名: 6-[[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]amino]-2-methoxy-3-methylpyrimidin-4-one
• CAS: 160053-36-1
• 化学式: C₁₁H₁₇N₃O₆
• 分子量: 287.272
• InChiKey: KSJAIBASXNKEFK-KNPZVZKISA-N

物化性质

• 沸点：
  515.5±60.0 °C(predicted)
• 密度：
  1.65±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-methoxy-3-methyl-6-β-D-xylofuranosylaminopyrimidin-4-(3H)-one 在 4-二甲氨基吡啶 、 溶剂黄146 、 sodium nitrite 作用下， 反应 72.25h， 生成 2-methoxy-3-methyl-5-nitroso-6-(2,3,5-tri-O-acetyl-β-D-xylofuranosylamino)pyrimidin-4-(3H)-one
  参考文献：
  名称：

  Selective Synthesis of 6-Ribo- (and Xylo) Pyrano and Furano Aminopyrimidines¹. Anticancer and Anti-AIDS Activities

  摘要：

  The synthesis and the anticancer and anti-AIDS activity of some 6-ribo (and xylo) pyrano and furano aminopyrimidines have been carried out. Isomerization to ribopyranose has been observed when per-O-acyl ribofuranoses were deprotected under basic medium.

  DOI：

  10.1080/15257779408013254
• 作为产物：
  描述：

  6-氨基-2-甲氧基-3-甲基-4(3H)-嘧啶酮 在 硫酸氢铵 、 sodium methylate 、 四氯化锡 作用下， 反应 27.0h， 生成 2-methoxy-3-methyl-6-β-D-xylofuranosylaminopyrimidin-4-(3H)-one
  参考文献：
  名称：

  Selective Synthesis of 6-Ribo- (and Xylo) Pyrano and Furano Aminopyrimidines¹. Anticancer and Anti-AIDS Activities

  摘要：

  The synthesis and the anticancer and anti-AIDS activity of some 6-ribo (and xylo) pyrano and furano aminopyrimidines have been carried out. Isomerization to ribopyranose has been observed when per-O-acyl ribofuranoses were deprotected under basic medium.

  DOI：

  10.1080/15257779408013254

文献信息

• Selective Synthesis of 6-Ribo- (and Xylo) Pyrano and Furano Aminopyrimidines¹. Anticancer and Anti-AIDS Activities
  作者：M. Nogueras、J. Cobo、M. L. Quijano、M. Melguizo、A. Sánchez、M. Melgarejo

  DOI：10.1080/15257779408013254

  日期：1994.3

  The synthesis and the anticancer and anti-AIDS activity of some 6-ribo (and xylo) pyrano and furano aminopyrimidines have been carried out. Isomerization to ribopyranose has been observed when per-O-acyl ribofuranoses were deprotected under basic medium.