1-(5-(4-ethylphenyl)-2-methylfuran-3-yl)ethanone | 1428905-35-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(5-(4-ethylphenyl)-2-methylfuran-3-yl)ethanone
• 英文别名: 1-[5-(4-ethylphenyl)-2-methylfuran-3-yl]ethanone
• CAS: 1428905-35-4
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: BGDGIYOLLOENLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-ethyl-4-(2-methoxyvinyl)benzene 、 乙酰丙酮 在 indium(III) triflate 、 氧气 、 palladium diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 75.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以82%的产率得到1-(5-(4-ethylphenyl)-2-methylfuran-3-yl)ethanone
  参考文献：
  名称：

  Pd(II)-Catalyzed Sequential C–C/C–O Bond Formations: A New Strategy to Construct Trisubstituted Furans

  摘要：

  Palladium-catalyzed oxidative difunctionalization of enol ethers with 1,3-dicarbonyl compounds to construct trisubstituted furans in one step under mild conditions is described. The reaction is thought to proceed through a C-C bond formation along with a C-O bond closing the ring structure. Oxygen is the sole oxidant regenerating the Pd(II) catalyst.

  DOI：

  10.1021/ol400451t

文献信息

• Pd(II)-Catalyzed Sequential C–C/C–O Bond Formations: A New Strategy to Construct Trisubstituted Furans
  作者：Meifang Zheng、Liangbin Huang、Wanqing Wu、Huanfeng Jiang

  DOI：10.1021/ol400451t

  日期：2013.4.19

  Palladium-catalyzed oxidative difunctionalization of enol ethers with 1,3-dicarbonyl compounds to construct trisubstituted furans in one step under mild conditions is described. The reaction is thought to proceed through a C-C bond formation along with a C-O bond closing the ring structure. Oxygen is the sole oxidant regenerating the Pd(II) catalyst.