3-fluoro-2-hydroxy-5-perfluorooctylbenzaldehyde | 1254926-98-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-fluoro-2-hydroxy-5-perfluorooctylbenzaldehyde
• 英文别名: 3-Fluoro-5-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)-2-hydroxybenzaldehyde
• CAS: 1254926-98-1
• 化学式: C₁₅H₄F₁₈O₂
• 分子量: 558.167
• InChiKey: JCXRYOJNHNGEKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  2-碘代丙烷 、 3-fluoro-2-hydroxy-5-perfluorooctylbenzaldehyde 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and RCM Reactions Using a Recyclable Grubbs−Hoveyda Metathesis Catalyst Activated by a Light Fluorous Tag

  摘要：

  A recyclable Grubbs-Hoveyda second-generation catalyst activated by a light fluorous tag was prepared The modified light fluorous catalyst exhibited higher catalytic activity than the parent or the previously reported light fluorous variant for RCM reactions and could be routinely recovered The light fluorous tag incorporated in the catalyst served as both an activator as well as a handle for separation and recovery with fluorous solid-phase extraction

  DOI：

  10.1021/jo101140w
• 作为产物：
  描述：

  全氟辛基碘烷 、 3-氟-2-羟基苯甲醛 在 偶氮二甲氧基异庚腈 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以12%的产率得到3-fluoro-2-hydroxy-5-perfluorooctylbenzaldehyde
  参考文献：
  名称：

  Synthesis and RCM Reactions Using a Recyclable Grubbs−Hoveyda Metathesis Catalyst Activated by a Light Fluorous Tag

  摘要：

  A recyclable Grubbs-Hoveyda second-generation catalyst activated by a light fluorous tag was prepared The modified light fluorous catalyst exhibited higher catalytic activity than the parent or the previously reported light fluorous variant for RCM reactions and could be routinely recovered The light fluorous tag incorporated in the catalyst served as both an activator as well as a handle for separation and recovery with fluorous solid-phase extraction

  DOI：

  10.1021/jo101140w