N-prop-2-ynylisoquinolin-1-amine | 1420042-00-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-prop-2-ynylisoquinolin-1-amine
• CAS: 1420042-00-7
• 化学式: C₁₂H₁₀N₂
• 分子量: 182.225
• InChiKey: BDZCLEAPROMOEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-prop-2-ynylisoquinolin-1-amine 以 水 为溶剂， 反应 1.0h， 以95%的产率得到3-methylimidazo[2,1-a]isoquinoline
  参考文献：
  名称：

  Synthesis of Imidazo[1,2-a]pyridines: “Water-Mediated” Hydroamination and Silver-Catalyzed Aminooxygenation

  摘要：

  Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intra-molecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.

  DOI：

  10.1021/jo3025303

文献信息

• Synthesis of Imidazo[1,2-<i>a</i>]pyridines: “Water-Mediated” Hydroamination and Silver-Catalyzed Aminooxygenation
  作者：Darapaneni Chandra Mohan、Sadu Nageswara Rao、Subbarayappa Adimurthy

  DOI：10.1021/jo3025303

  日期：2013.2.1

  Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intra-molecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.