6-chloro-3-(4-chloro-benzyl)-3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline | 41957-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-3-(4-chloro-benzyl)-3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline
• 英文别名: 6-Chloro-3-(4-chlorobenzyl)-3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline；6-chloro-3-[(4-chlorophenyl)methyl]-2,4-dihydropyrido[3,2-h][1,3]benzoxazine
• CAS: 41957-84-0
• 化学式: C₁₈H₁₄Cl₂N₂O
• 分子量: 345.228
• InChiKey: NNZCKBDKGWOHKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 对氯苄胺 、 5-氯-8-羟基喹啉 生成 6-chloro-3-(4-chloro-benzyl)-3,4-dihydro-2H-[1,3]oxazino[5,6-h]quinoline
  参考文献：
  名称：

  抗疟药。2.二氢-1，3-恶嗪基喹啉和二氢-1，3-吡啶苯并恶嗪。

  摘要：

  DOI：

  10.1021/jm00262a006

文献信息

• FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE
  申请人：Padmanabhan Radhakrishnan

  公开号：US20110224207A1

  公开（公告）日：2011-09-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• Flavivirus Inhibitors and Methods of Their Use
  申请人：Padmanabhan Radhakrishnan

  公开号：US20140038962A1

  公开（公告）日：2014-02-06

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• US8563580B2
  申请人：——

  公开号：US8563580B2

  公开（公告）日：2013-10-22
• US8906937B2
  申请人：——

  公开号：US8906937B2

  公开（公告）日：2014-12-09
• [FR] INHIBITEUR DE FLAVIVIRUS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV GEORGETOWN

  公开号：WO2010039538A2

  公开（公告）日：2010-04-08

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.