glucosamine sulfate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: glucosamine sulfate
• 英文别名: D-glucosamine sulfate；glucosamine sulphate；(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol;sulfuric acid
• 化学式: C₆H₁₃NO₅*H₂O₄S
• 分子量: 277.252
• InChiKey: VSKBNXJTZZAEPH-NSEZLWDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.91
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  199
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  glucosamine sulfate 在 sodium chloride 作用下， 以 水 、 丙酮 为溶剂， 反应 3.5h， 以99.6%的产率得到glucosamine sulfate sodium chloride
  参考文献：
  名称：

  一种硫酸氨基葡萄糖氯化钠复盐的制备方法

  摘要：

  本发明公开了一种硫酸氨基葡萄糖氯化钠复盐的制备方法，涉及硫酸氨基葡萄糖氯化钠复盐制备技术领域，具体包括以下步骤：S1，D‑氨基葡萄糖制备，S2，D‑硫酸氨基葡萄糖制备，S3，取D‑硫酸氨基葡萄糖溶于质量比为1：2～1:5的水中，加入当量比为1.0:1.0～1.2的氯化钠，室温搅拌至全溶，过滤，滤液于水浴经油泵减压浓缩，加入丙酮，搅拌，室温静止，过滤，再用丙酮洗涤；固体产物水泵减压除去丙酮，水浴经油泵减压干燥至恒重，得硫酸氨基葡萄糖氯化钠复盐，本发明以D‑盐酸氨基葡萄糖为原料经与二正丙胺置换制备D‑氨基葡萄糖,相比离子交换柱法，溶剂用量少，收率高,工艺简单。

  公开号：

  CN112898356A
• 作为产物：
  描述：

  2-氨基-2-脱氧葡萄糖盐酸盐 在 potassium hydroxide 、 硫酸 作用下， 以 水 为溶剂， 30.0~50.0 ℃ 、60.0 kPa 条件下， 反应 14.5h， 以99.5%的产率得到glucosamine sulfate
  参考文献：
  名称：

  一种硫酸氨基葡萄糖的制备方法

  摘要：

  本发明涉及一种硫酸氨基葡萄糖的制备方法。本发明技术方案是：第一步将D‑氨基葡萄糖盐酸盐分散到醇溶剂中；第二步用碱中和D‑氨基葡萄糖盐酸盐；第三步向D‑氨基葡萄糖溶液中滴加硫酸成盐；第四步析出分离；第五步精制：反复用少量有机溶剂洗涤固体，至无氯离子洗出后，减压干燥；所述的有机试剂为浓度在80%～100%的乙醇、丙醇、丙酮等。本发明技术方案获得了低钠或低钾含量的硫酸氨基葡萄糖。

  公开号：

  CN104710483B

文献信息

• Halide-free glucosamine sulfate compositions and methods of preparation
  申请人：JFC Technolries, LLC

  公开号：US07388001B1

  公开（公告）日：2008-06-17

  Glucosamine sulfate having a purity of at least about 99 wt. %, and a maximum halide content of about 0.01 wt. %. Preferably, the glucosamine sulfate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers; polypropylene glycol homopolymers and copolymers; ethylcellulose; povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated glucosamine sulfate composition will be stable at ambient temperatures and upon exposure to the atmosphere.

  葡萄糖胺硫酸盐的纯度至少为约99重量％，最大卤化物含量约为0.01重量％。最好的是，通过用至少一种药用可接受的聚合物包覆来稳定葡萄糖胺硫酸盐，该聚合物包括水溶性，水不相容和/或水肿胀的均聚物和/或共聚物。适用的聚合物包括羧基聚甲酸乙烯酯均聚物和共聚物；聚乙二醇均聚物和共聚物；聚丙二醇均聚物和共聚物；乙基纤维素；聚维酮均聚物和共聚物；聚丙烯酸均聚物和共聚物；聚丙烯酰胺均聚物和共聚物；多糖；以及两种或更多上述聚合物的混合物。由此产生的包覆葡萄糖胺硫酸盐组成物在常温下和暴露于大气中时将保持稳定。
• Glucosamine sulfate metal chloride compositions and process of preparing
  申请人：Jame Fine Chemicals, Inc.

  公开号：US05902801A1

  公开（公告）日：1999-05-11

  Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e. the cation, is lithium, sodium, magnesium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with the metal sulfate in the presence of water to form an aqueous solution of glucosamine sulfate metal chloride and thereafter freeze-drying the solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.

  含有葡萄糖胺硫酸盐金属氯化物的葡萄糖胺组合物，其中金属即阳离子为锂、钠、镁、锌或锰。该化合物的纯度水平至少为约97%，水含量最多为约10重量％，基于该组合物的重量。该化合物是通过将葡萄糖胺盐酸盐与金属硫酸盐在水的存在下接触，形成葡萄糖胺硫酸盐金属氯化物的水溶液，然后在温度和减压下冷冻干燥一段时间，以使水的重量至少去除约90重量％，并将葡萄糖胺硫酸盐金属氯化物的分解限制在最多约3％。
• Glucosamine anchored cancer targeted nano-vesicular drug delivery system of doxorubicin
  作者：Smita Pawar、Pradeep Vavia

  DOI：10.3109/1061186x.2015.1055572

  日期：2016.1.2

  Background: Efficacy of an anticancer drug is challenged by severe adverse effects persuaded by the drug itself; hence designing a tumour targeted delivery system is chosen as an objective of this research work.Purpose: We propose, glucose transporter targeting ligand, i.e. synthesised N-lauryl glucosamine (NLG) anchored doxorubicin (DOX) in niosomal formulation.Methods: Synthesised NLG was incorporated into niosomal formulation of DOX using Span 60 as surfactant, cholesterol as membrane stabilizer and dicetyl phosphate (DCP) as stabilizer.Results: The formulation was stable with particle size of 1105nm, zeta potential -30 +/- 5mV and entrapment efficiency approximately 95%. DSC and XRD pattern of freeze-dried formulation demonstrated encapsulation of DOX in niosomal formulation. Cytotoxicity of targeted niosomal formulation (IC50=0.830ppm) was higher than non-targeted niosomal formulation (IC50=1.369ppm) against B6F10 melanoma cell lines. In vitro cellular internalization revealed that targeted niosomal formulation was internalised more efficiently with higher cellular retention by cancer cells compared to the non-targeted niosomal formulation and free DOX. In vitro receptor binding and docking study of targeted niosomal formulation had shown the comparative association potential with glucose receptor.Conclusion: NLG anchored niosomal formulation of DOX with enhanced cytotoxicity, internalization and receptor binding potential has implication in targeted cancer therapy.
• OKADA, YOSHIHITO;SHIBATA, SHOJI;IKEKAWA, TETSURO;JAVELLANA, ANA M. J.;KAM+, PHYTOCHEMISTRY, 26,(1987) N 10, 2789-2796
  作者：OKADA, YOSHIHITO、SHIBATA, SHOJI、IKEKAWA, TETSURO、JAVELLANA, ANA M. J.、KAM+

  DOI：——

  日期：——
• WEARABLE ITEM FOR INCREASED APPLICATION OF NUTRIENTS
  申请人：The Vitasken Venture Club

  公开号：US20200338342A1

  公开（公告）日：2020-10-29

  A wearable item is formed of conductive fibers and non-conductive fibers. Encapsulated nutrients are placed on the non-conductive fibers. A voltage is placed on the conductive lines in order to induce an electric field so that the effective absorption rate of the nutrients through the skin of a user is increased.