(E)-5-methyl-1,5-heptadien-4-ol | 62036-50-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-5-methyl-1,5-heptadien-4-ol
• 英文别名: (5E)-5-methylhepta-1,5-dien-4-ol
• CAS: 62036-50-4
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: DZMNWBJXNUQUME-FNORWQNLSA-N

物化性质

• 沸点：
  184.6±9.0 °C(Predicted)
• 密度：
  0.858±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-5-methyl-1,5-heptadien-4-ol 在 potassium hydrogensulfate 作用下， 生成 5-Methyl-1,3,5-heptatrien
  参考文献：
  名称：

  Microbiological survey of dialysate: Vantage of use of sterile bag concentrate

  摘要：

  SummaryHaemodialysed patients are exposed to nearly 400 litres of dialysis water weekly. The bacterial contamination of treated dialysate and water induces acute pyrogenic reactions or chronic damage and cytokine activation.The aim of this study was to value the microbiological parameters of dialysis water and dialysate of our monitors by bacterial culture (measured as colony forming units [CFU]) of water samples at 37 °C after 48 hours, at 22 °C after 72 hours and after seven days, and by measuring endotoxin levels (endotoxin units [EU]).In our centre, there are 16 monitors (6 monitors use sterile dialysate fluid and 10 monitors use non sterile dialysate fluid). The chemicals used for disinfection are chlorine and paracetic acid. Water samples were taken under sterile procedures every three months for a year.No bacteria were found in the samples of water of the dialysis ring; EU were lower than the limit value of 0.25 EU/ml fixed by the European Pharmacopoeia.The concentration of CFU and EU of the dialysate, taken from monitors with a sterile bag, were lower than those of other monitors (p < 0.05 t Student test). However, the levels of CFU/ml and EU/ml of dialysate samples, taken from monitors with a non‐sterile bag, were lower than the guideline value of the European Pharmacopoeia (v.n. CFU < 50 CFU/ml and EU < 0,05 EU/ml).Frequent examination of CFU and EU is essential to reduce the damage caused by the use of contaminated water, therefore the goal of future dialytic techniques will be the use of “sterile dialysate”.

  DOI：

  10.1111/j.1755-6686.2001.tb00160.x
• 作为产物：
  描述：

  反式-2-甲基-2-丁烯醛 、 3-溴丙烯 在 锌 作用下， 以 乙醚 为溶剂， 反应 6.0h， 以94%的产率得到(E)-5-methyl-1,5-heptadien-4-ol
  参考文献：
  名称：

  柱头蛋白A的正式全合成

  摘要：

  已经描述了一种高效，立体选择性的方法，用于Stigmatellin A的正式全合成。该合成中涉及的关键步骤是双环烯烃的不对称化以引入两个甲基和两个羟基手性中心，Friedel Crafts酰化，区域选择性脱甲基，Baker-Venkataraman重排和Grubbs交叉复分解。

  DOI：

  10.1016/j.tetlet.2017.08.048

文献信息

• Mild bottom-up synthesis of indium(0) nanoparticles: characterization and application in the allylation of carbonyl compounds
  作者：Viviana Dorn、Alicia Chopa、Gabriel Radivoy

  DOI：10.1039/c5ra27928c

  日期：——

  Very reactive, monodisperse (4.0 ± 0.5 nm) spherical indium(0) nanoparticles have been generated in situ, in a simple, mild and efficient way, by fast reduction of commercially available indium(III) chloride with lithium sand and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB) in THF, at room temperature, and in the absence of any anti-agglomeration additives or ligands. The as-synthesized

  通过用锂砂快速还原市售的氯化铟（III）和催化量的二甲基甲酰胺（III），以简单，温和和有效的方式就地生成了高反应性的单分散（4.0±0.5 nm）球形铟（0）纳米颗粒。在室温下，在不存在任何抗团聚添加剂或配体的情况下，在THF中的4,4'-二叔丁基联苯（DTBB）。合成后的裸InNP用于各种醛和酮的烯丙基化。对于大多数测试的化合物，以良好至优异的产率获得了相应的均烯丙基醇作为主要产物。
• Regio- and Diastereoselective Ene Reaction of 4-Phenyl-1,2,4-triazoline-3,5-dione with Chiral Allylic Alcohols and Their Derivatives
  作者：Ay-Hua Gau、Guey-Liang Lin、Biing-Jiun Uang、Fen-Ling Liao、Sue-Lein Wang

  DOI：10.1021/jo980835g

  日期：1999.4.1

  Chiral allylic alcohols la-e reacted with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) in CH2Cl2 to produce 3-amino-1-alken-4-ols 2 and 3 in 78-89% yields, with 68-90% diastereomeric excess (de) in favor of the three isomer. Chiral allylic ethers If,g and acetates Ih,i gave similar yields but lower de (34-66%). Reaction of allylic alcohols 6a-e with PTAD in CH2Cl2 produced 1,3-regioisomers 7 and 8 exclusively in 33-65% yields without apparent diastereoselectivity, except when R-1 was a Bu-t group, in which case only syn product 7 was formed. However, when 6a or 6c was subjected to reaction with PTAD in a polar solvent, up to 88% de was observed. Reaction of allylic ethers 6f,g and acetates 6h,i with PTAD in CH2Cl2 also produced 7 and 8 exclusively with improved yields (56-96%) and diastereoselectivity (50-100% de in favor of the syn isomer).
• Thermal rearrangement of a 2-methylenebicyclo[2.1.1]hexane
  作者：Thomas Gibson

  DOI：10.1021/jo00319a006

  日期：1981.3
• GIBSON T., J. ORG. CHEM., 1981, 46, NO 6, 1073-1076
  作者：GIBSON T.

  DOI：——

  日期：——
• Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines
  作者：Moritz Balkenhohl、Sebastian Kölbl、Tony Georgiev、Erick M. Carreira

  DOI：10.1021/jacsau.1c00176

  日期：2021.7.26