2-Anilino-4-aminothiazol-5-carbonsaeure-methylester | 13807-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Anilino-4-aminothiazol-5-carbonsaeure-methylester
• 英文别名: 4-amino-2-anilino-thiazole-5-carboxylic acid methyl ester；4-amino-2-phenylamino-thiazole-5-carboxylic acid methyl ester；Methyl 4-amino-2-anilino-1,3-thiazole-5-carboxylate
• CAS: 13807-17-5
• 化学式: C₁₁H₁₁N₃O₂S
• mdl: MFCD11983260
• 分子量: 249.293
• InChiKey: JIFKUQJTZMOTRV-UHFFFAOYSA-N

物化性质

• 熔点：
  185-188 °C
• 沸点：
  424.1±48.0 °C(Predicted)
• 密度：
  1.397±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-Anilino-4-aminothiazol-5-carbonsaeure-methylester 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Three-component condensation of 2,4-diaminothiazoles with aldehydes and Meldrum's acid: synthesis of 7-aryl(alkyl)-substituted 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones

  摘要：

  The new method of the synthesis of 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones, based on decarboxylation of corresponding 2,4-diamino-5-thiazolecarboxylic acids has been elaborated; unstable derivatives of 2,4-diaminothiazole, generated in situ as a result of decarboxylation, react with aldehydes and Meldrum's acid forming target compounds.

  DOI：

  10.1016/j.mencom.2009.03.011
• 作为产物：
  描述：

  氰胺 、 氯乙酸甲酯 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以60%的产率得到2-Anilino-4-aminothiazol-5-carbonsaeure-methylester
  参考文献：
  名称：

  WO2007/19191

  摘要：

  公开号：

文献信息

• Use of 2,4-diaminothiazole derivatives
  申请人：——

  公开号：US20010039275A1

  公开（公告）日：2001-11-08

  2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.

  抑制GSK-3（糖原合成激酶-3）的2,4-二氨基噻唑衍生物，对治疗和/或预防GSK-3抑制有益的疾病和疾病特别有效，尤其是阿尔茨海默病、双相情感障碍、糖耐量受损（IGT）、1型糖尿病、2型糖尿病和肥胖症。
• [EN] 2,4-DIAMINOTHIAZOLE DERIVATIVES AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 (GSK-3) INHIBITORS<br/>[FR] DERIVES DE 2,4-DIAMINOTHIAZOLE
  申请人：NOVO NORDISK AS

  公开号：WO2001056567A1

  公开（公告）日：2001-08-09

  2,4-Diaminothiazole derivatives which inhibit GSK-3 (glycogen synthase kinase-3) and which are useful for the treatment and/or prevention disorders and diseases wherein an inhibition of GSK-3 is beneficial, especially especially Alzheimer's disease, bipolar disorder, IGT (impaired glucose tolerance), Type 1 diabetes, Type 2 diabetes and obesity.

  2,4-二氨基噻唑衍生物抑制GSK-3（糖原合成酶激酶-3），对于治疗和/或预防抑制GSK-3有益的疾病和疾病特别是阿尔茨海默病、双相情感障碍、IGT（糖耐量受损）、1型糖尿病、2型糖尿病和肥胖症具有用处。
• Thiazolopyrimidine kinase inhibitors
  申请人：Binnun Eva

  公开号：US20070185139A1

  公开（公告）日：2007-08-09

  The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the thereof as inhibitors of ATP-protein kinase interactions.

  本发明涉及公式（I）的新型噻唑嘧啶化合物，或其形式或组合物，以及它们作为ATP-蛋白激酶相互作用抑制剂的应用。
• Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors
  申请人：Janssen Pharmaceutica N.V.

  公开号：US07605154B2

  公开（公告）日：2009-10-20

  The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.

  本发明涉及一种新的噻唑嘧啶化合物，其化学式为（I），或其形式或组合物，以及其作为ATP-蛋白激酶相互作用抑制剂的用途。
• Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
  作者：Ronghui Lin、Sigmond G. Johnson、Peter J. Connolly、Steven K. Wetter、Eva Binnun、Terry V. Hughes、William V. Murray、Niranjan B. Pandey、Sandra J. Moreno-Mazza、Mary Adams、Angel R. Fuentes-Pesquera、Steven A. Middleton

  DOI：10.1016/j.bmcl.2009.02.067

  日期：2009.4

  2,7-Diamino-thiazolo[4,5-d]pyrimidine analogues were synthesized as novel epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities and inhibited in vitro cellular proliferation in EGFR-overexpressing human tumor cells. The synthesis and preliminary biological, physical, and pharmacokinetic evaluation of these thiazolopyrimidine compounds are reported. (C) 2009 Elsevier Ltd. All rights reserved.