6-guanidino quinoline | 109682-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-guanidino quinoline
• 英文别名: [6]quinolyl-guanidine；[6]Chinolyl-guanidin；1-(6-Quinolyl)guanidine；2-quinolin-6-ylguanidine
• CAS: 109682-36-2
• 化学式: C₁₀H₁₀N₄
• 分子量: 186.216
• InChiKey: ICFVZTXDLVZZRJ-UHFFFAOYSA-N

物化性质

• 沸点：
  360.1±34.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-氨基喹啉 、 氰胺 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 48.0h， 以57%的产率得到6-guanidino quinoline
  参考文献：
  名称：

  Direct Guanylation of Amino Groups by Cyanamide in Water: Catalytic Generation and Activation of Unsubstituted Carbodiimide by Scandium(III) Triflate

  摘要：

  Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds.

  DOI：

  10.1055/s-0033-1341080

文献信息

• Lactam compounds useful as protein kinase inhibitors
  申请人：Blackburn Christopher

  公开号：US20090105213A1

  公开（公告）日：2009-04-23

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶的抑制剂。本发明还提供了包括本发明化合物的药物组合物以及使用该组合物治疗各种疾病的方法。
• LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Blackburn Christopher

  公开号：US20120178739A1

  公开（公告）日：2012-07-12

  The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

  本发明提供了一种新型化合物，可用作蛋白激酶抑制剂。本发明还提供了包含所述化合物的药物组合物，以及使用该组合物治疗各种疾病的方法。
• 273. Synthetic antimalarials. Part XXXVIII. 2-(6′-Quinolylguanidino)-4-β-diethylaminoethylamino- and 4-(6′-quinolylguanidino)-2-β-diethylaminoethylamino-6-methylpyrimidines
  作者：J. M. Gulland、P. E. Macey

  DOI：10.1039/jr9490001257

  日期：——
• US7459448B2
  申请人：——

  公开号：US7459448B2

  公开（公告）日：2008-12-02
• Direct Guanylation of Amino Groups by Cyanamide in Water: Catalytic Generation and Activation of Unsubstituted Carbodiimide by Scandium(III) Triflate
  作者：Katsunori Tanaka、Kazuki Tsubokura、Takayuki Iwata、Misako Taichi、Almira Kurbangalieva、Koichi Fukase、Yoichi Nakao

  DOI：10.1055/s-0033-1341080

  日期：——

  Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds.