2-(3,5-bis-trifluoromethylphenyl)-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N-methyl isobutyramide | 825643-73-0

分子结构分类

有机化合物 - 有机杂环化合物 - 吡啶及其衍生物

中文名称

——

中文别名

——

英文名称

2-(3,5-bis-trifluoromethylphenyl)-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N-methyl isobutyramide

英文别名

2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide；2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide

2-(3,5-bis-trifluoromethylphenyl)-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N-methyl isobutyramide化学式

CAS

825643-73-0

化学式

C₂₅H₂₀ClF₇N₂O

mdl

——

分子量

532.888

InChiKey

GPIQHPBJRAPFDV-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

7.6
重原子数：

36
可旋转键数：

4
环数：

3.0
sp3杂化的碳原子比例：

0.28
拓扑面积：

33.2
氢给体数：

0
氢受体数：

9

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide	401891-53-0	C₂₄H₁₈Cl₂F₆N₂O	535.316
——	(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)methylamine	825643-62-7	C₁₃H₁₂ClFN₂	250.703

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-6-(3-hydroxy-propylamino)-pyridin-3-yl]-N-methyl-isobutyramide	——	C₂₈H₂₈F₇N₃O₂	571.538
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-ethenyl-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide	1301660-54-7	C₂₇H₂₃F₇N₂O	524.481
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide	1301660-56-9	C₂₆H₂₁F₇N₂O₂	526.454
——	2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-6-(2-hydroxy-ethylsulfanyl)-pyridin-3-yl]-N-methyl-isobutyramide	——	C₂₇H₂₅F₇N₂O₂S	574.563
——	ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate	1301660-58-1	C₃₀H₂₇F₇N₂O₃	596.545
——	2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-[2,3']bipyridinyl-5-yl]-N-methyl-isobutyramide	——	C₃₀H₂₄F₇N₃O	575.529
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-(4-(4-fluoro-2-methylphenyl)-6-{[(2S)-2-pyrrolidinylmethyl]amino}-3-pyridinyl)-N,2-dimethylpropanamide	929047-61-0	C₃₀H₃₁F₇N₄O	596.591
——	5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylic acid	1301660-69-4	C₂₆H₂₁F₇N₂O₃	542.453
——	(S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(3-methylpiperazin-l-yl)pyridin-3-yl]-N-methylisobutyramide	1379446-14-6	C₃₀H₃₁F₇N₄O	596.591
——	methyl 5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinecarboxylate	1301660-71-8	C₂₇H₂₃F₇N₂O₃	556.48
——	[5'-{[2-(3,5-bistrifluoromethylphenyl)-2-methylpropanoyl]methylamino}-4'-(4-fluoro-2-methylphenyl)-3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridine-4-yl]acetic acid	——	C₃₃H₃₄F₇N₃O₃	653.64
——	(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide	825640-97-9	C₃₀H₃₀F₇N₃O₂	597.576
——	[5'-{[2-(3,5-bistrifluoromethylphenyl)-2-methylpropyl]methylamino}-4'-(4-fluoro-2-methylphenyl)-3,3-dimethyl-3,4,5,6-tetrahydro-[1,2']bipyridinyl-4-yl]acetic acid	——	C₃₄H₃₆F₇N₃O₃	667.667
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(5-oxo-3-pyrrolidinyl)-3-pyridinyl]-N,2-dimethylpropanamide	1301659-84-6	C₂₉H₂₆F₇N₃O₂	581.533
——	4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(4-fluoro-2-methylphenyl)pyridin-2-yl)cyclohexane-1-carboxylic acid	——	C₃₂H₃₁F₇N₂O₃	624.599
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(octahydro-2H-pyrazino[1,2-a]pyrazin-2-yl)-3-pyridinyl]-N,2-dimethylpropanamide	929047-74-5	C₃₂H₃₄F₇N₅O	637.644
——	ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}-(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3-oxopropanoate	1301660-72-9	C₃₀H₂₇F₇N₂O₄	612.544
——	(R)-N-[6-(4-benzyl-2-methyl-piperazin-1-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide	825644-79-9	C₃₇H₃₇F₇N₄O	686.716
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-(hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-3-pyridinyl]-N,2-dimethylpropanamide	929046-19-5	C₃₂H₃₃F₇N₄O₂	638.628
——	methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-(([(1,1-dimethylethyl)oxy]carbonyl)amino)-4-pentynoate	1195787-84-8	C₃₆H₃₆F₇N₃O₅	723.688
——	methyl (2S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-(([(1,1-dimethylethyl)oxy]carbonyl)amino)-4-pentynoate	1195787-69-9	C₃₆H₃₆F₇N₃O₅	723.688
——	ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-nitrobutanoate	1301660-61-6	C₃₁H₃₀F₇N₃O₅	657.585
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(2,2-dimethyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide	1301660-34-3	C₃₁H₃₀F₇N₃O₂	609.587
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(2,2-dimethyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide	1301660-36-5	C₃₁H₃₀F₇N₃O₂	609.587
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-(2,2-dimethyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide	1301660-38-7	C₃₁H₃₀F₇N₃O₂	609.587
——	methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)pyridin-2-yl]-2-[(tert-butoxycarbonyl)amino]-2-methylpent-4-ynoate	1195787-94-0	C₃₇H₃₈F₇N₃O₅	737.715
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	——	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301659-93-7	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-15-0	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-12-7	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-13-8	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[3-(hydroxymethyl)-5-oxo-2-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-04-7	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[3-(hydroxymethyl)-5-oxo-2-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-03-6	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[3-(hydroxymethyl)-5-oxo-2-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-05-8	C₃₀H₂₈F₇N₃O₃	611.559
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[3-(hydroxymethyl)-5-oxo-2-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-07-0	C₃₀H₂₈F₇N₃O₃	611.559
——	dimethyl {1-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-nitroethyl}propanedioate	1301661-17-5	C₃₂H₃₀F₇N₃O₇	701.595
——	N-[6-(2-acetyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide	1301661-12-0	C₃₁H₂₈F₇N₃O₃	623.57
——	1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxylate	1301660-62-7	C₃₄H₃₄F₇N₃O₄	681.65
——	2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[4-(hydroxymethyl)-4-methyl-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide	1301660-52-5	C₃₁H₃₀F₇N₃O₃	625.586
——	N-[6-[4,4-bis(hydroxymethyl)-5-oxo-3-pyrrolidinyl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide	1301660-43-4	C₃₁H₃₀F₇N₃O₄	641.586