7-cyclopentylcamptothecin | 1103530-09-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: 7-cyclopentylcamptothecin
• 英文别名: CPT-c5；(19S)-10-cyclopentyl-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• CAS: 1103530-09-1
• 化学式: C₂₅H₂₄N₂O₄
• 分子量: 416.477
• InChiKey: SXKOJZHNQIRLHX-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-cyclopentylcamptothecin 在 钾硼氢 、 二乙胺基三氟化硫 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 (S,S)-7-cyclopentyl-21-fluorocamptothecin
  参考文献：
  名称：

  提高内酯代谢稳定性的新策略：（20 S，21 S）-21-氟喜树碱作为新型的，水解稳定的拓扑异构酶I抑制剂的发现

  摘要：

  内酯是具有生物活性的天然产物中的常见结构基序。然而，内酯的代谢不稳定性显着降低了其体内效力。在本研究中，通过设计α-氟醚作为内酯的新型生物等排体，提供了提高内酯代谢稳定性的新策略。通过发现（20 S，21 S）-21-氟喜树碱为水解稳定的拓扑异构酶I抑制剂，证实了α-氟醚/内酯替代的有效性。高效喜树碱衍生物8升已成功鉴定出具有良好的体外和体内抗肿瘤活性，并代表了发现新型抗肿瘤药物的有希望的先导。有趣的是，这项研究还为喜树碱的C21-羰基提供了新的结构-活性关系，这被认为是必不可少的药效团。我们的结果表明，保守的C21-羰基可被氟取代基取代。α-氟醚可普遍用于改善内酯的代谢稳定性。

  DOI：

  10.1021/jm400906z
• 作为产物：
  描述：

  溴代环戊烷 、 喜树碱 在 叔丁基过氧化氢 、 硫酸 、 二苯基硅烷 、 溶剂黄146 作用下， 以 丙酮 为溶剂， 生成 7-cyclopentylcamptothecin
  参考文献：
  名称：

  7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation

  摘要：

  A series of 7-cycloalkylcamptothecin derivatives were synthesized from camptothecin with two methods. Their biological activities in vitro were evaluated with sulforhodamine-B (SRB) method on four types of human tumor cell lines A549/ATCC, HT29, NCI-H460 and HL60. Most of these camptothecin analogues show higher antitumor activity than the reference compounds SN-38 and Topotecan, with the IC50 values low to nM level. Structure-activity relationship studies of these compounds mostly match the conclusion we achieved before from quantitative structure-activity relationship (QSAR) research. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.010

文献信息

• Semi-synthesis and biological activity of γ-lactones analogs of camptothecin
  作者：Mingzong Li、Weidong Tang、Fuxing Zeng、Liguang Lou、Tianpa You

  DOI：10.1016/j.bmcl.2008.10.074

  日期：2008.12

  A series of E-ring gamma-lactone camptothecin derivatives were synthesized by semi-synthesis via a three-step domino reaction. Their biological activity was evaluated on two types of human tumor cell lines A549 and HT-29 with sulforhodamine-B (SRB) method. The antitumor activity of these compounds was lower than SN-38, only compound 12c was found to be close to the activity of Topotecan. The structure-activity

  通过三步多米诺反应通过半合成法合成了一系列E环γ-内酯喜树碱衍生物。用磺基罗丹明-B（SRB）方法评估了它们在两种类型的人类肿瘤细胞系A549和HT-29上的生物学活性。这些化合物的抗肿瘤活性低于SN-38，仅发现化合物12c接近托泊替康的活性。研究和讨论了这些类似物的结构-活性关系（SAR）。
• 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation
  作者：Mingzong Li、Wei Jin、Chen Jiang、Chao Zheng、Weidong Tang、Tianpa You、Liguang Lou

  DOI：10.1016/j.bmcl.2009.06.010

  日期：2009.8

  A series of 7-cycloalkylcamptothecin derivatives were synthesized from camptothecin with two methods. Their biological activities in vitro were evaluated with sulforhodamine-B (SRB) method on four types of human tumor cell lines A549/ATCC, HT29, NCI-H460 and HL60. Most of these camptothecin analogues show higher antitumor activity than the reference compounds SN-38 and Topotecan, with the IC50 values low to nM level. Structure-activity relationship studies of these compounds mostly match the conclusion we achieved before from quantitative structure-activity relationship (QSAR) research. (C) 2009 Elsevier Ltd. All rights reserved.
• A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20<i>S</i>,21<i>S</i>)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors
  作者：Zhenyuan Miao、Lingjian Zhu、Guoqiang Dong、Chunlin Zhuang、Yuelin Wu、Shengzheng Wang、Zizao Guo、Yang Liu、Shanchao Wu、Shiping Zhu、Kun Fang、Jianzhong Yao、Jian Li、Chunquan Sheng、Wannian Zhang

  DOI：10.1021/jm400906z

  日期：2013.10.24

  was validated by the discovery of (20S,21S)-21-fluorocamptothecins as hydrolytically stable topoisomerase I inhibitors. A highly potent camptothecin derivative, 8l, was successfully identified, which showed excellent in vitro and in vivo antitumor activities and represents a promising lead for the discovery of novel antitumor agents. Interestingly, this study also provided a new structure–activity

  内酯是具有生物活性的天然产物中的常见结构基序。然而，内酯的代谢不稳定性显着降低了其体内效力。在本研究中，通过设计α-氟醚作为内酯的新型生物等排体，提供了提高内酯代谢稳定性的新策略。通过发现（20 S，21 S）-21-氟喜树碱为水解稳定的拓扑异构酶I抑制剂，证实了α-氟醚/内酯替代的有效性。高效喜树碱衍生物8升已成功鉴定出具有良好的体外和体内抗肿瘤活性，并代表了发现新型抗肿瘤药物的有希望的先导。有趣的是，这项研究还为喜树碱的C21-羰基提供了新的结构-活性关系，这被认为是必不可少的药效团。我们的结果表明，保守的C21-羰基可被氟取代基取代。α-氟醚可普遍用于改善内酯的代谢稳定性。