propyloxyl | 16499-18-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: propyloxyl
• 英文别名: 1-propoxy radical；n-Propoxy radical
• CAS: 16499-18-6
• 化学式: C₃H₇O
• 分子量: 59.088
• InChiKey: JAVBBFXUGDCHLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  4
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  propyloxyl 在 氧化亚氮 作用下， 289.0 ℃ 、13.33 kPa 条件下， 生成 亚硝酸丙酯
  参考文献：
  名称：

  Rate constants for the reactions of C2H5O, i-C3H7O, and n-C3H7O with NO and O2 as a function of temperature

  摘要：

  The rate constants of the reactions of ethoxy (C2H5O), i-propoxy (i-C3H7O) and n-propoxy (n-C3H7O) radicals with O-2 and NO have been measured as a function of temperature. Radicals have been generated by laser photolysis from the appropriate alkyl nitrite and have been detected by laser-induced fluorescence. The following Arrhenius expressions have been determined:(R-1) C2H5O + O-2 --> products k(1) = (2.4 +/- 0.9) X 10(-14) exp(-2.7 +/- 1.0 kJmol(-1)/RT) cm(3) s(-1) 295K < T < 354K p = 100 Torr(R-2) i-C3H7O + O-2 --> products k(2) = (1.6 +/- 0.2) X 10(-14) exp(-2.2 +/- 0.2 kJmol(-1)/RT) cm(3) s(-1) 288K < T < 364K p = 50-200 Torr(R-3) n-C3H7O + O-2 --> products k(3) = (2.5 +/- 0.5) X 10(-14) exp(-2.0 +/- 0.5 kJmol(-1)/RT) cm(3) s(-1) 289K < T < 381K p = 30-100 Torr(R-4) C2H5O + NO --> products k(4) = (2.0 +/- 0.7) X 10(-11) exp(0.6 +/- 0.4 kJmol(-1)/RT) cm(3) s(-1) 286K < T < 388K p = 30-500 Torr(R-5) i-C3H7O + NO --> products k(5) = (8.9 +/- 0.21 x 10(-12) exp(3.3 +/- 0.5 kJmol(-1)/RT) cm(3) s(-1) 286K < T < 389K p = 30-500 Torr(R-6) n-C3H7O + NO --> products k(6) = (1.2 +/- 0.2) X 10(-11) exp(2.9 +/- 0.4 kJmol(-1)/RT) cm(3)s(-1) 289K < T < 380K p = 30-100 TorrAll reactions have been found independent of total pressure between 30 and 500 Torr within the experimental error. (C) 1999 John Wiley & Sons, Inc.

  DOI：

  10.1002/(sici)1097-4601(1999)31:12<860::aid-kin4>3.0.co;2-e
• 作为产物：
  描述：

  亚硝酸丙酯 生成 propyloxyl
  参考文献：
  名称：

  歧化烷氧基与一氧化氮的比例

  摘要：

  DOI：

  10.1021/j100259a041

文献信息

• Effects of oral and transdermal 17β-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women
  作者：Christopher P. Spencer、Ian F. Godsland、Alison J. Cooper、David Ross、Malcolm I. Whitehead、John C. Stevenson

  DOI：10.1053/meta.2000.6238

  日期：2000.6

  Few studies have examined the effects of 17 beta-estradiol on parameters of insulin and glucose metabolism. We studied 42 healthy, untreated postmenopausal women seeking relief from menopausal symptoms. They were randomized to receive either oral 17 beta-estradiol 2 mg daily combined with sequential oral norethindrone acetate (NETA) 1 mg daily from days 12 to 22, or transdermal 17 beta-estradiol 0.05 mg daily combined with sequential oral NETA 1 mg daily from days 17 to 28. Intravenous glucose tolerance tests (IVGTTs) were performed at baseline and after 48 weeks (estrogen-alone phase) and 48 weeks (combined phase) of completed therapy. Mathematical modeling analysis of plasma glucose, insulin, and C-peptide concentration profiles provided measures of insulin resistance, secretion, and elimination. Both types of therapy were associated with a decrease in fasting insulin and glucose levels. Insulin sensitivity was increased by oral estradiol during the estrogen-alone phase but was reversed by the addition of NETA. Transdermal estradiol did not affect insulin sensitivity. Hepatic insulin uptake and insulin secretion were increased with both types of treatment. The oral regimen of estradiol therapy was favorable to both insulin elimination and sensitivity. Transdermal estradiol therapy had relatively few effects on insulin metabolism. Copyright (C) 2000 by W.B. Saunders Company.
• Khatoon, T.; Edelbuettel-Einhaus, J.; Hoyermann, K., Berichte der Bunsen-Gesellschaft, 1989, vol. 93, p. 626 - 632
  作者：Khatoon, T.、Edelbuettel-Einhaus, J.、Hoyermann, K.、Wagner, H. Gg.

  DOI：——

  日期：——
• Rehorek, Detlef, Zeitschrift fur Chemie, 1980, vol. 20, # 8, p. 312 - 313
  作者：Rehorek, Detlef

  DOI：——

  日期：——
• Mix, K.-H.; Schliephake, V.; Wagner, H. Gg., Zeitschrift fur physikalische Chemie (Neue Folge), 1986, vol. 150, p. 17 - 30
  作者：Mix, K.-H.、Schliephake, V.、Wagner, H. Gg.

  DOI：——

  日期：——
• Temperature-dependent kinetics studies of the reactions of C2H5O2 andn-C3H7O2 radicals with NO
  作者：J�rg Eberhard、Carleton J. Howard

  DOI：10.1002/(sici)1097-4601(1996)28:10<731::aid-kin3>3.0.co;2-o

  日期：——

  The rate coefficients for the gas-phase reactions of C2H5O2 and n-C3H7O2 radicals with NO have been measured over the temperature range of (201-403) K using chemical ionization mass spectrometric detection of the peroxy radical, The alkyl peroxy radicals were generated by reacting alkyl radicals with O-2, where the alkyl radicals were produced through the pyrolysis of a larger alkyl nitrite. In some cases C2H5 radicals were generated through the dissociation of iodoethane in a low-power radio Frequency discharge. The discharge source was also tested for the i-C3H7O2 + NO reaction, yielding k(298 K) = (9.1 +/- 1.5) x 10(-12) cm(3) molecule(-1) s(-1), in excellent agreement with our previous determination. The temperature dependent rate s coefficients were found to be k(T) = (2.6 +/- 0.4) x 10(-12) exp(380 +/- 70)/T} cm(3) molecule(-1) s(-1) and = 12.9 +/- 0.5) x 10(-12) exp(350 +/- 60)T} cm(3) molecule(-1) s(-1) for the reactions of C2H5O2 and n-C3H7O2 radicals with NO, respectively. The rate coefficients at 298 K derived from these Arrhenius expressions are k = (9.3 +/- 1.6) x 10(-12) cm(3) molecule(-1) s(-1) for C2H5O2 radicals and k = (9.4 +/- 1.6) x 10(-12) cm(3) molecule(-1) s(-1) for n-C2H5O2 radicals. (C) 1996 John Wiley & Sons, Inc.