Aceton- | 6261-85-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Aceton-
• 英文别名: N-[(4-methoxyphenyl)methoxy]propan-2-imine
• CAS: 6261-85-4
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: PAUHINZYZZHROO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Aceton- 、 苯甲醛 在 叔丁基过氧化氢 、 palladium diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 8.0h， 以88%的产率得到(5-methoxy-2-(((propan-2-ylideneamino)oxy)methyl)phenyl)(phenyl)methanone
  参考文献：
  名称：

  钯催化的O-芳基甲基和芳基取代的乙肟醚的直接单芳基化

  摘要：

  已经开发出一种有效的钯催化的O-芳基甲基和芳基取代的乙肟醚的邻芳基化反应。这种方法具有较高的单上门的选择性，并且不需要外源性配体。在简单的外切-乙酰肟辅助剂的指导下，各种掩蔽的芳基甲醇和苯酚以及各种芳族醛均与这种转化相容，这很可能遵循一种涉及六元或五元外-环palpalated中间体的机制途径。可以方便地采用该策略来制备具有合成价值的1 H-苯并[ d ] [1,2]恶嗪和苯并[ d]异恶唑。可以容易地从产物中除去导向基团，以提供官能化的二芳基酮。

  DOI：

  10.1039/c8ob01400k
• 作为产物：
  描述：

  丙酮肟 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 1.0h， 以70%的产率得到Aceton-
  参考文献：
  名称：

  Direct ortho-C–H Functionalization of Aromatic Alcohols Masked by Acetone Oxime Ether via exo-Palladacycle

  摘要：

  Use of an iridium catalyst allowed the efficient dehydrogenative functionalization of C-H bonds of azulenes with the production of hydrogen as the sole byproduct. The reaction occurred with excellent chemo- and regioselectivities to provide 2-silylazulenes even without any directing groups. Effective conjugation through the 2-position of the azulene ring was demonstrated by the unique stimuli-responsiveness against an acidbase reaction.

  DOI：

  10.1021/acs.orglett.5b00594

文献信息

• HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE
  申请人：Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center

  公开号：US20140073634A1

  公开（公告）日：2014-03-13

  The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
• Direct <i>ortho</i>-C–H Functionalization of Aromatic Alcohols Masked by Acetone Oxime Ether via <i>exo</i>-Palladacycle
  作者：Kun Guo、Xiaolan Chen、Mingyu Guan、Yingsheng Zhao

  DOI：10.1021/acs.orglett.5b00594

  日期：2015.4.3

  Use of an iridium catalyst allowed the efficient dehydrogenative functionalization of C-H bonds of azulenes with the production of hydrogen as the sole byproduct. The reaction occurred with excellent chemo- and regioselectivities to provide 2-silylazulenes even without any directing groups. Effective conjugation through the 2-position of the azulene ring was demonstrated by the unique stimuli-responsiveness against an acidbase reaction.
• Palladium-catalyzed direct <i>mono</i>-aroylation of <i>O</i>-arylmethyl and aryl-substituted acetoxime ethers
  作者：Ling-Yan Shao、Zhi Xu、Cun-Ying Wang、Xiao-Pan Fu、Miao-Miao Chen、Hong-Wei Liu、Ya-Fei Ji

  DOI：10.1039/c8ob01400k

  日期：——

  An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers has been developed; this method has high mono-site selectivity and does not require exogenous ligands. Under the direction of a simple exo-acetoxime auxiliary, a broad scope of masked arylmethyl alcohols and phenols as well as various aromatic aldehydes are compatible with this transformation, which

  已经开发出一种有效的钯催化的O-芳基甲基和芳基取代的乙肟醚的邻芳基化反应。这种方法具有较高的单上门的选择性，并且不需要外源性配体。在简单的外切-乙酰肟辅助剂的指导下，各种掩蔽的芳基甲醇和苯酚以及各种芳族醛均与这种转化相容，这很可能遵循一种涉及六元或五元外-环palpalated中间体的机制途径。可以方便地采用该策略来制备具有合成价值的1 H-苯并[ d ] [1,2]恶嗪和苯并[ d]异恶唑。可以容易地从产物中除去导向基团，以提供官能化的二芳基酮。