{4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxo(6-hydroquinolyl)}-N-benzylcarboxamide | 668423-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: {4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxo(6-hydroquinolyl)}-N-benzylcarboxamide
• 英文别名: {4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxo(6-hydroquinolyl)}-N-benzylcarboxamide；4-amino-N-benzyl-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-2-oxo-1H-quinoline-6-carboxamide
• CAS: 668423-05-0
• 化学式: C₂₉H₂₉N₇O₂
• 分子量: 507.595
• InChiKey: ZJQHYAYIOMPFGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxohydroquinoline-6-carboxylic acid hydrochloride 在 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 48.0h， 生成 {4-amino-3-[5-(4-methylpiperazinyl)benzimidazol-2-yl]-2-oxo(6-hydroquinolyl)}-N-benzylcarboxamide
  参考文献：
  名称：

  [EN] BENZIMIDAZOLE QUINOLINONES AND USES THEREOF
  [FR] QUINOLINONES DE BENZIMIDAZOLE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2004018419A3

文献信息

• Benzimidazole quinolinones and uses thereof
  申请人：Barsanti Paul A.

  公开号：US20090281100A1

  公开（公告）日：2009-11-12

  Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.

  提供了抑制各种酶和治疗各种疾病的方法，包括向受试者施用I或IB结构化合物，其药学上可接受的盐，其互变异构体或其药学上可接受的互变异构体盐。具有结构I和IB的化合物具有以下结构，并具有此处描述的变量。这些化合物可以用于制备药物，用于抑制各种酶的作用，并用于治疗由这些酶介导的疾病。
• Pharmaceutically acceptable salts of quinolinone compounds and their medical use
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP2762475A1

  公开（公告）日：2014-08-06

  A salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R1-R9 and R12-R14 are as defined herein

  式 I 化合物的盐或该化合物的同系物，其中式 I 具有如下结构，R1-R9 和 R12-R14 如本文所定义
• Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors
  作者：Paul A. Renhowe、Sabina Pecchi、Cynthia M. Shafer、Timothy D. Machajewski、Elisa M. Jazan、Clarke Taylor、William Antonios-McCrea、Christopher M. McBride、Kelly Frazier、Marion Wiesmann、Gena R. Lapointe、Paul H. Feucht、Robert L. Warne、Carla C. Heise、Daniel Menezes、Kimberly Aardalen、Helen Ye、Molly He、Vincent Le、Jayesh Vora、Johanna M. Jansen、Mary Ellen Wernette-Hammond、Alex L. Harris

  DOI：10.1021/jm800790t

  日期：2009.1.22

  The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and metastasis, has been a major focus in oncology research over the last several years. Many potent small molecule inhibitors of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) kinases have been evaluated. More recently, compounds that act through the complex inhibition of multiple kinase targets have been reported and may exhibit improved clinical efficacy. We report herein a series of potent, orally efficacious 4-amino3-benzimidazol-2-ylhydroquinolin-2-one analogues as inhibitors of VEGF, PDGF, and fibroblast growth factor (FGF) receptor tyrosine kinases. Compounds in this class, such as 5 (TK1258), are reversible ATP-competitive inhibitors of VEGFR-2, FGFR-1, and PDGFR beta with IC50 values <0.1 mu M. On the basis of its favorable in vitro and in vivo properties, compound 5 was selected for clinical evaluation and is currently in phase I clinical trials.
• US7470709B2
  申请人：——

  公开号：US7470709B2

  公开（公告）日：2008-12-30
• US7825132B2
  申请人：——

  公开号：US7825132B2

  公开（公告）日：2010-11-02