2,2-difluoro-N-(3-oxo-3-phenylpropyl)acetamide | 1160852-94-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-difluoro-N-(3-oxo-3-phenylpropyl)acetamide
• 英文别名: Bang57
• CAS: 1160852-94-7
• 化学式: C₁₁H₁₁F₂NO₂
• 分子量: 227.211
• InChiKey: BDDKUAOEYZJCJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氟乙酸乙酯 、 3-amino-1-phenylpropan-1-one hydrochloride 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 以85%的产率得到2,2-difluoro-N-(3-oxo-3-phenylpropyl)acetamide
  参考文献：
  名称：

  Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-xL

  摘要：

  Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-x(L). Since Bang52 bears no resemblance to any chemical binder of Bcl-x(L) we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.067

文献信息

• Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-xL
  作者：Matteo Rossi、Jeong-kyu Bang、Sharlyn Mazur、Jaclyn A. Iera、Darren C. Phillips、Gerard P. Zambetti、Daniel H. Appella

  DOI：10.1016/j.bmcl.2009.03.067

  日期：2009.5

  Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-x(L). Since Bang52 bears no resemblance to any chemical binder of Bcl-x(L) we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis. (c) 2009 Elsevier Ltd. All rights reserved.