(E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide | 134835-00-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide
• 英文别名: (E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenyl-acrylamide；(E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylprop-2-enamide
• CAS: 134835-00-0
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: ZZDXZMGURCBCRN-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基肉桂醛 、 亚硝基苯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成 (E)-N-hydroxy-3-(4-methoxyphenyl)-N-phenylacrylamide
  参考文献：
  名称：

  WO2008/115153

  摘要：

  公开号：

文献信息

• N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS
  申请人：Zhang Yugen

  公开号：US20100105921A1

  公开（公告）日：2010-04-29

  A process for preparing hydroxamic acids is provided. The process comprises reacting an aldehyde with a nitroso compound in the presence of a N-heterocyclic carbene (NHC) catalyst.

  提供了一种制备羟肟酸的过程。该过程包括在N-杂环卡宾（NHC）催化剂的存在下将醛与亚硝基化合物反应。
• N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids
  申请人：Agency for Science, Technology and Research

  公开号：US08143423B2

  公开（公告）日：2012-03-27

  A process for preparing hydroxamic acids is provided. The process comprises reacting an aldehyde with a nitroso compound in the presence of a N-heterocyclic carbene (NHC) catalyst.

  提供了一种制备羟肟酸的方法。该方法包括在N-杂环卡宾（NHC）催化剂的存在下，将醛与亚硝基化合物反应。
• N-Heterocyclic Carbene (NHC)-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds
  作者：Fong Tian Wong、Pranab K. Patra、Jayasree Seayad、Yugen Zhang、Jackie Y. Ying

  DOI：10.1021/ol8004276

  日期：2008.6.1

  NHC-catalyzed direct amidation of aldehydes with nitroso compounds is a powerful method for the synthesis of N-arylhydroxamic acids. A variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were found to give excellent yields of the corresponding N-arylhydroxamic acids. This chemistry was also extended to the synthesis of chiral N-arylhydroxamic acids by kinetic resolution of a-branched aldehydes, a domino amidation-redox amination reaction of acrolein, and a three-component reaction for the synthesis of N-arylaziridines.
• POKROVSKAYA, I. E.;STARIKOVA, Z. A.;ELISEEVA, L. N.;RYABOKOBYLKO, YU. S.;+, ZH. OBSHCH. XIMII, 60,(1990) N1, S. 2597-2604
  作者：POKROVSKAYA, I. E.、STARIKOVA, Z. A.、ELISEEVA, L. N.、RYABOKOBYLKO, YU. S.、+

  DOI：——

  日期：——
• US8143423B2
  申请人：——

  公开号：US8143423B2

  公开（公告）日：2012-03-27