2-cyano-4-hydroxy-cinnamic acid | 119935-63-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-cyano-4-hydroxy-cinnamic acid
• 英文别名: 2-Cyan-4-hydroxy-zimtsaeure；(E)-3-(2-cyano-4-hydroxyphenyl)prop-2-enoic acid
• CAS: 119935-63-6
• 化学式: C₁₀H₇NO₃
• 分子量: 189.17
• InChiKey: UUWGERKZCVYLKW-DUXPYHPUSA-N

物化性质

• 沸点：
  434.6±40.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-cyano-4-hydroxy-cinnamic acid 在 盐酸 作用下， 生成 3-(2-carboxy-4-hydroxy-phenyl)-3-hydroxy-propionic acid
  参考文献：
  名称：

  DE416073

  摘要：

  公开号：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 对甲苯磺酰氯 作用下， 生成 2-cyano-4-hydroxy-cinnamic acid
  参考文献：
  名称：

  DE416073

  摘要：

  公开号：

文献信息

• Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products
  申请人：——

  公开号：US20030228259A1

  公开（公告）日：2003-12-11

  Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessible to direct sampling by sampling metabolic derivatives and catabolic products in accessible biological samples are disclosed herein.

  本发明公开了确定生物分子生物合成或分解速率的方法，具体为通过取样可获取的生物样本中的代谢衍生物和分解产物，测量难以或不易直接取样的生物分子的生物合成和分解速率。
• CYCLIC PEPTIDES AND METHODS OF USE THEREOF
  申请人：Regents of the University of Minnesota

  公开号：US20200115416A1

  公开（公告）日：2020-04-16

  Certain embodiments of the invention provide a cyclic compound of formula I: wherein: Pro is a residue of L-proline; X 1 is a residue of Arg or DArg; X 2 is a residue of Phe or DPhe; X 3 is a residue of Phe, DPhe or hPhe; X 4 is a residue of a natural or unnatural amino acid; X 5 is a residue of Ala, Asp, Glu, Lys, His, Phe, Ser, Leu or Gly; X 6 is a residue of Phe, Ala, Gly, Ser, Lys, Asp, Leu, Nle, Trp, Tyr, Cha or hPhe; and DPro is a residue of D-proline; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.

  发明的某些实施例提供了一个公式I的环状化合物： 其中：Pro是L-脯氨酸的残基；X1是Arg或DArg的残基；X2是Phe或DPhe的残基；X3是Phe、DPhe或hPhe的残基；X4是天然或非天然氨基酸的残基；X5是Ala、Asp、Glu、Lys、His、Phe、Ser、Leu或Gly的残基；X6是Phe、Ala、Gly、Ser、Lys、Asp、Leu、Nle、Trp、Tyr、Cha或hPhe的残基；而DPro是D-脯氨酸的残基；或其盐。某些实施例还提供了包含这种化合物的组合物，以及使用这种化合物和组合物的方法。
• Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase
  申请人：YALE UNIVERSITY

  公开号：US20140356322A1

  公开（公告）日：2014-12-04

  The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.

  本发明涉及双功能化合物，其作为靶向泛素化的调节剂具有实用性，特别是作为本发明的双功能化合物对各种被降解和/或受到抑制的多肽和其他蛋白质的抑制剂。具体而言，本发明涉及含有一端结合泛素连接酶的VHL配体，另一端结合靶蛋白的基团的化合物，使得靶蛋白靠近泛素连接酶以促使该蛋白的降解（和抑制）。本发明展示了与本发明化合物相关的广泛的药理活性范围，与靶向多肽的降解/抑制一致。
• [EN] INHIBITOR IMAGING AGENTS<br/>[FR] AGENTS INHIBITEURS D'IMAGERIE
  申请人：AMERSHAM PLC

  公开号：WO2005049005A1

  公开（公告）日：2005-06-02

  The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.

  本发明揭示了一种成像试剂，其中包括一种特定类型的矩阵金属蛋白酶抑制剂（MMPi's），属于磺胺基羟肟类，并标记有成像基团，可用于哺乳动物体内成像和诊断的诊断成像试剂。
• [EN] OPTICAL IMAGING CONTRAST AGENTS FOR IMAGING LUNG CANCER<br/>[FR] AGENTS DE CONTRASTE D'IMAGERIE OPTIQUE POUR L'IMAGERIE DU CANCER DU POUMON
  申请人：AMERSHAM HEALTH AS

  公开号：WO2005058370A1

  公开（公告）日：2005-06-30

  The invention provides contrast agents for optical imaging of lung cancer in patients. The contrast agents may be used in diagnosis of lung cancer, for follow up of progress in disease development, for follow up of treatment of lung cancer and for surgical guidance. Further, the invention provides methods for optical imaging of lung cancer in patients.

  该发明提供了用于患者肺癌光学成像的对比剂。这些对比剂可用于肺癌的诊断，用于随访疾病发展进展，用于随访肺癌治疗以及用于手术引导。此外，该发明还提供了患者肺癌光学成像的方法。