4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid | 263758-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid
• CAS: 263758-69-6
• 化学式: C₁₂H₁₃NO₇
• 分子量: 283.238
• InChiKey: HUWJSTCEZBSJIZ-UHFFFAOYSA-N

物化性质

• 熔点：
  154.5 °C
• 沸点：
  541.8±50.0 °C(Predicted)
• 密度：
  1.380±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid 在 盐酸 、 sodium cyanoborohydride 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、533.29 Pa 条件下， 反应 0.33h， 生成 (2,4,5-Trichlorophenyl) 4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]butanoate
  参考文献：
  名称：

  Probing the Role of Polyphenol Oxidation in Mediating Insect−Pathogen Interactions. Galloyl-Derived Electrophilic Traps for the Lymantria dispar Nuclear Polyhedrosis Virus Matrix Protein Polyhedrin

  摘要：

  Galloyl-derived orthoquinone probes have been designed, synthesized, and utilized in an ongoing study of insect-pathogen interactions. A stable galloyl-derived orthoquinone O-methyl ether modified with both acidic and fluorescent appendages was successful in trapping the model nucleophile cysteine, a test protein bearing a single cysteine residue, and the viral occlusion body matrix protein polyhedrin from Lymantria dispar nuclear polyhedrosis virus (LdNPV), a pathogen of the gypsy moth caterpillar (GMc). This latter observation may be related to the molecular mechanism by which gallotannins decrease LdNPV infectivity in GMc's. Sufficient site isolation was not achieved with a polymer-bound reactive galloyl hydroxyorthoquinone electrophile to permit similar nucleophile trapping to compete with oligomerization.

  DOI：

  10.1021/jo982477n
• 作为产物：
  描述：

  香草醛 在 硝酸 、 potassium carbonate 、 三氟乙酸 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid
  参考文献：
  名称：

  Photodegradable Macromers and Hydrogels for Live Cell Encapsulation and Release

  摘要：

  DOI：

  10.1021/ja309004c

文献信息

• Improved Utility of Photolabile Solid Phase Synthesis Supports for the Synthesis of Oligonucleotides Containing 3‘-Hydroxyl Termini
  作者：Hariharan Venkatesan、Marc M. Greenberg

  DOI：10.1021/jo951550w

  日期：1996.1.1

  and cleaved from, a solid phase support (6) using the o-nitrobenzyl intramolecular photochemical redox reaction. The yields of isolated oligonucleotides relative to yields obtained using conventional hydrolytic cleavage vary between 67% and 82.5%. Synthesis of oligonucleotides using phosphoramidites that do not contain N-benzoyl protecting groups enables one to photolytically cleave the biopolymers

  使用邻硝基苄基分子内光化学氧化还原反应在固相载体（6）上合成寡核苷酸并从其裂解。相对于使用常规水解裂解获得的产率，分离的寡核苷酸的产率在67％至82.5％之间变化。使用不包含N-苯甲酰基保护基的亚磷酰胺合成寡核苷酸，使得人们能够使用通常可用的UV辐射源以高产率光解所述生物聚合物。t标记表明在使用透射照明器从6进行多胸苷酸酯的光解过程中，形成了少于3％的胸苷。胸苷光二聚体。通过HPLC分析从6进行光解切割后获得的酶消化寡核苷酸，未检测到UV诱导的损伤。
• Identification of Compounds Modifying A Cellular Response
  申请人：Thastrup Ole

  公开号：US20090239755A1

  公开（公告）日：2009-09-24

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.

  本发明涉及识别能够调节细胞反应的化合物的方法。该方法涉及将活细胞附着在包含测试化合物库的固体支撑体上。测试化合物通过可切割的连接剂与固体支撑体连接，因此可以从固体支撑体释放出来。选择细胞被固体支撑体调节了感兴趣的细胞反应的固体支撑体，并且可以鉴定固体支撑体上的测试化合物。细胞反应可以是蛋白质复合物形成的变化，例如。
• Compounds Modifying Apoptosis
  申请人：Thastrup Ole

  公开号：US20080194537A1

  公开（公告）日：2008-08-14

  The present invention relates to compounds capable of inhibiting binding of the Smac protein to Inhibitors of apoptosis (IAPs). Such compounds are preferably capable of inhibiting IAP and thus may promote apoptosis or sensitize cells for apoptosis. The compounds may be used in the treatment of proliferative diseases, such as cancer.

  本发明涉及一种能够抑制Smac蛋白与凋亡抑制剂（IAPs）结合的化合物。这些化合物最好能够抑制IAP，从而可能促进细胞凋亡或增加细胞对凋亡的敏感性。这些化合物可用于治疗增生性疾病，如癌症。
• IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE
  申请人：Thastrup Ole

  公开号：US20130123140A1

  公开（公告）日：2013-05-16

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.

  本发明涉及识别能够调节细胞响应的化合物的方法。该方法包括将活细胞附着在包含一系列测试化合物的固体支持物上。测试化合物通过可切断的连接物与固体支持物相连，因此可以从固体支持物中释放出来。选择细胞响应已被调节的固体支持物，并可以鉴定固体支持物中的测试化合物。例如，细胞响应可以是蛋白质之间复合物形成的变化。
• ENZYME-ASSISTED SPATIAL DECORATION OF BIOMATERIALS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150104427A1

  公开（公告）日：2015-04-16

  A method of producing a hydrogel compromising a spatially-controlled, three-dimensional distribution of one or more bioactive signals is provided. The method compromises illuminating the hydrogel, wherein the hydrogel compromises a polymer bound to a peptide comprising a photolabile protected amino acid, wherein at least one portion of the hydrogel is illuminated to deprotect the protected amino acid, thereby converting the protected amino acid to a deprotected amino acid. Preferably, the deprotected amino acid is a substrate for an enzyme in at least one portion of the hydrogel. The method further comprises the step of contacting the hydrogel with the enzyme and a peptide comprising a bioactive signal, wherein the enzyme can form a bond between the substrate and the peptide comprising the bioactive signal, thereby producing a hydrogel compromising a plurality of bioactive signals occupying three dimensions of the hydrogel within at least one portion of the hydrogel subjected to illumination.

  本发明提供了一种生产具有空间控制的、三维分布一种或多种生物活性信号的水凝胶的方法。该方法包括照射水凝胶，其中水凝胶包括与多肽结合的聚合物，该多肽包括光敏保护氨基酸，其中至少水凝胶的一部分被照射以去除保护氨基酸，从而将保护氨基酸转化为去保护氨基酸。优选地，去保护氨基酸是水凝胶中至少一部分中酶的底物。该方法进一步包括将酶和含有生物活性信号的多肽接触水凝胶，其中酶能够在底物和含有生物活性信号的多肽之间形成键，从而在至少一部分被照射的水凝胶中产生占据三维水凝胶内的多种生物活性信号的水凝胶。