1-{4-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]phenyl}ethanone | 1027382-34-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-{4-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]phenyl}ethanone
• 英文别名: 1-{4-[1-(Tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]phenyl}ethanone；1-[4-[1-[tert-butyl(dimethyl)silyl]oxy-2,2,2-trichloroethyl]phenyl]ethanone
• CAS: 1027382-34-8
• 化学式: C₁₆H₂₃Cl₃O₂Si
• 分子量: 381.802
• InChiKey: JQPYGIJAAVRYGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.32
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-乙酰苯甲醛 、 sodium trichloroacetate 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.67h， 以91%的产率得到1-{4-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]phenyl}ethanone
  参考文献：
  名称：

  tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes

  摘要：

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.072

文献信息

• tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes
  作者：Lauren R. Cafiero、Timothy S. Snowden

  DOI：10.1016/j.tetlet.2008.02.072

  日期：2008.4

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.