3-(2-hydroxybenzoyl)-1-butanol | 1345020-16-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-hydroxybenzoyl)-1-butanol
• 英文别名: 4-Hydroxy-1-(2-hydroxyphenyl)-2-methylbutan-1-one；4-hydroxy-1-(2-hydroxyphenyl)-2-methylbutan-1-one
• CAS: 1345020-16-7
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: BKEJBAWSVPBLMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-hydroxybenzoyl)-1-butanol 在 sodium tetrahydroborate 、 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以78%的产率得到trans-2-(3-methyl-tetrahydrofuran-2-yl)-phenol
  参考文献：
  名称：

  Catalytic Hydroacylation as an Approach to Homoaldol Products

  摘要：

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.

  DOI：

  10.1021/ol202663p
• 作为产物：
  描述：

  3-丁烯-1-醇 、 水杨醛 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 二苯基甲氧基膦 、 sodium acetate 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以97%的产率得到3-(2-hydroxybenzoyl)-1-butanol
  参考文献：
  名称：

  Catalytic Hydroacylation as an Approach to Homoaldol Products

  摘要：

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.

  DOI：

  10.1021/ol202663p

文献信息

• Catalytic Hydroacylation as an Approach to Homoaldol Products
  作者：Stephen K. Murphy、David A. Petrone、Matthew M. Coulter、Vy M. Dong

  DOI：10.1021/ol202663p

  日期：2011.12.2

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.