N-hydroxy-2-oxo-propionimidoyl chloride | 17019-27-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-hydroxy-2-oxo-propionimidoyl chloride
• 英文别名: 1-chloro-oxopropanal 1-oxime；(Z)-N-hydroxy-2-oxo-propionimidoyl chloride；(Z)-Pyruvohydroximoylchlorid；Pyruvohydroximoyl chloride；(1Z)-N-hydroxy-2-oxopropanimidoyl chloride
• CAS: 17019-27-1
• 化学式: C₃H₄ClNO₂
• 分子量: 121.523
• InChiKey: KCMDLQKACKNGMB-HYXAFXHYSA-N

物化性质

• 熔点：
  105-106 °C
• 沸点：
  220.7±23.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-hydroxy-2-oxo-propionimidoyl chloride 生成 2-semicarbazono-propionohydroximoyl chloride
  参考文献：
  名称：

  ALIPHATIC NITRO KETONES

  摘要：

  DOI：

  10.1021/jo01125a018
• 作为产物：
  描述：

  1-硝基乙酮 在 盐酸 作用下， 生成 N-hydroxy-2-oxo-propionimidoyl chloride
  参考文献：
  名称：

  ALIPHATIC NITRO KETONES

  摘要：

  DOI：

  10.1021/jo01125a018

文献信息

• 1,2,3-triazole insecticides
  申请人：Schering Agrochemicals Limited

  公开号：US05064844A1

  公开（公告）日：1991-11-12

  Compounds of formula I ##STR1## and N-oxides thereof, in which Ar is aryl; R.sup.1 and R.sup.2 are the same or different and are hydrogen, alkyl, alkenyl or alkynyl, each of which is optionally substituted, aryl, heterocyclyl, cyano, halogen, nitro, XR.sup.3, S(O).sub.2 NR.sup.4 R.sup.5, CHO and functional derivatives thereof, NR.sup.4 R.sup.5 or CYNR.sup.4 R.sup.5 ; R.sup.3 is hydrogen or optionally substituted alkyl or alkenyl; R.sup.4 and R.sup.5 are the same or different and are hydrogen, optionally substituted alkyl, acyl or aryl, or together with the nitrogen to which they are attached, form a 5 to 7 membered ring which can contain other hetero atoms; X is O, S, S(O).sub.n, OSO.sub.2, YCO or COO; Y is O or S; and n is 1 or 2; have pesticidal activity and especially insecticidal and acaricidal activity. Many of the compounds are novel.

  化学式I的化合物及其N-氧化物，其中Ar是芳基；R.sup.1和R.sup.2相同或不同，可以是氢、烷基、烯基或炔基，每个都可以是可选择取代的芳基、杂环基、氰基、卤素、硝基、XR.sup.3、S(O).sub.2 NR.sup.4 R.sup.5、CHO及其它功能衍生物、NR.sup.4 R.sup.5或CYNR.sup.4 R.sup.5；R.sup.3是氢或可选择取代的烷基或烯基；R.sup.4和R.sup.5相同或不同，可以是氢、可选择取代的烷基、酰基或芳基，或者与它们连接的氮一起形成一个含有其他杂原子的5到7元环；X是O、S、S(O).sub.n、OSO.sub.2、YCO或COO；Y是O或S；n是1或2；具有杀虫活性，尤其是杀虫和杀螨活性。其中许多化合物是新颖的。
• New syntheses of α-oximno-α-haloketones : reactions of α-haloketones with alkyl thionitrites
  作者：Yong Hae Kim、Sun Ho Jung

  DOI：10.1016/s0040-4039(01)82909-9

  日期：1981.1

  α-Oximino-α-haloketones were readily synthesized in good yields by treating α-haloketones with alkyl thionitrites under mild conditions.

  通过在温和的条件下用烷基亚硫氰酸盐处理α-卤代酮，可以轻松以高收率合成α-Oximino-α-卤代酮。
• Bianchi,G. et al., Journal of the Chemical Society. Perkin transactions I, 1974, p. 137 - 140
  作者：Bianchi,G. et al.

  DOI：——

  日期：——
• Substituted Tetrahydropyrrolo[2,1-<i>b</i>]oxazol-5(6<i>H</i>)-ones and Tetrahydropyrrolo[2,1-<i>b</i>]thiazol-5(6<i>H</i>)-ones as Hypoglycemic Agents
  作者：Thomas D. Aicher、Bork Balkan、Philip A. Bell、Leonard J. Brand、S. H. Cheon、Rhonda O. Deems、Jay B. Fell、William S. Fillers、James D. Fraser、Jiaping Gao、Douglas C. Knorr、Gerald G. Kahle、Christina L. Leone、Jeffrey Nadelson、Ronald Simpson、Howard C. Smith

  DOI：10.1021/jm9803121

  日期：1998.11.1

  A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-one and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. The in vivo hypoglycemic efficacy and potency of these compounds were evaluated in a model of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus), the ob/ob mouse. 25a(2S) (SDZ PGU 693) was selected for further pharmacological studies.
• Durio, Gazzetta Chimica Italiana, 1933, vol. 63, p. 747,748
  作者：Durio

  DOI：——

  日期：——