2-Bromo-1-(4-butoxyphenyl)propan-1-one | 92018-52-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Bromo-1-(4-butoxyphenyl)propan-1-one
• 英文别名: 2-bromo-1-(4-butoxyphenyl)propan-1-one
• CAS: 92018-52-5
• 化学式: C₁₃H₁₇BrO₂
• 分子量: 285.181
• InChiKey: KLFTYRRBLVRJKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,2-三氟乙酰胺 、 2-Bromo-1-(4-butoxyphenyl)propan-1-one 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 (RS)-2-trifluoroacetamido-1-(4-butoxyphenyl)-1-propanone
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064
• 作为产物：
  描述：

  1-(4-丁氧基苯基)丙烷-1-酮 在 溴 作用下， 生成 2-Bromo-1-(4-butoxyphenyl)propan-1-one
  参考文献：
  名称：

  5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

  摘要：

  A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.064

文献信息

• 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations
  申请人：Pickar Harrison James

  公开号：US20070135396A1

  公开（公告）日：2007-06-14

  The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:

  本发明涉及一种新的制剂，其中包含一种或多种雌激素和2-苯基-1-[4-(2-氨基乙氧基)苄基]-吲哚化合物，它们可用作雌激素类药物，以及使用这些化合物的制药组合物和治疗方法，其具有以下一般结构：
• 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
  申请人：Pickar Harrison James

  公开号：US20070142361A1

  公开（公告）日：2007-06-21

  The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:

  本发明涉及新的配方，其中包含一种或多种雌激素和2-苯基-1-[4-2-氨基乙氧基)-苄基]-吲哚化合物，这些化合物作为雌激素制剂是有用的，以及利用这些化合物的制药组合物和治疗方法，其具有以下一般结构：
• 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
  申请人：Miller P. Chris

  公开号：US20070054895A1

  公开（公告）日：2007-03-08

  The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating colon cancer.

  本发明涉及具有以下一般结构的新型2-苯基-1-[4-(2-氨基乙氧基)苄基]-吲哚化合物，其在治疗结肠癌方面具有用途。
• 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE AND ESTROGEN FORMULATIONS
  申请人：PICKAR James Harrison

  公开号：US20120252769A1

  公开（公告）日：2012-10-04

  The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structures below:

  本发明涉及一种包含一种或多种雌激素和2-苯基-1-[4-(2-氨乙氧基)-苯基]-吲哚化合物的新配方，这些化合物可用作雌激素类药剂，以及利用这些化合物的制药组合物和治疗方法，这些化合物具有以下一般结构：
• 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLES AS ESTROGENIC AGENTS
  申请人：Miller Chris P.

  公开号：US20090176764A1

  公开（公告）日：2009-07-09

  The present invention relates to new 2-Phenyl- 1 -[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in treating osteoporosis, acne, dysfunctional uterine bleeding, endometrial polyps, benign breast disease, adenomyosis, infertility, endometriosis, endometrial cancer, polycystic ovary syndrome, cardiovascular disease, Alzheimer's disease, cognitive decline, central nervous system disorders, central nervous system cancers, leukemia, endometrial ablations, chronic renal disease, chronic hepatic disease, coagulation diseases and disorders, hypocalcemia, hypercalcemia, Paget's disease, osteomalacia, osteohalisteresis, and multiple myeloma.

  本发明涉及新的2-苯基-1-[4-(2-氨基乙氧基)苯甲基]-吲哚化合物，其具有以下一般结构：这些化合物可用于治疗骨质疏松症、痤疮、功能性子宫出血、子宫内膜息肉、良性乳腺疾病、子宫内膜异位症、不孕症、子宫内膜癌、多囊卵巢综合症、心血管疾病、阿尔茨海默病、认知能力下降、中枢神经系统疾病、中枢神经系统癌症、白血病、子宫内膜消融、慢性肾脏疾病、慢性肝病、凝血疾病和紊乱、低钙血症、高钙血症、帕吉特病、软骨发育不全和多发性骨髓瘤的治疗。