5-tert-butyl-2-methoxythiophene | 142396-68-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-tert-butyl-2-methoxythiophene
• 英文别名: 5-t-Butyl-2-methoxythiophene；2-tert-butyl-5-methoxythiophene
• CAS: 142396-68-7
• 化学式: C₉H₁₄OS
• 分子量: 170.276
• InChiKey: KJDLYTWXCPXWOO-UHFFFAOYSA-N

物化性质

• 沸点：
  218.0±28.0 °C(Predicted)
• 密度：
  1.003±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-叔丁基噻吩 在 正丁基锂 、 硼酸三甲酯 、 双氧水 、 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 生成 5-tert-butyl-2-methoxythiophene
  参考文献：
  名称：

  Hinrichs, Heiko; Margaretha, Paul, Chemische Berichte, 1992, vol. 125, # 10, p. 2311 - 2318

  摘要：

  DOI：

文献信息

• PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US20200045968A1

  公开（公告）日：2020-02-13

  Pyridine compounds of Formula (1) are provided: wherein R1, R2, X, Y and Het are defined. The pyridine compounds can be used to treat or prevent plant diseases.

  提供了化合物的化学式（1）：其中R1、R2、X、Y和Het均已定义。这些吡啶化合物可用于治疗或预防植物疾病。
• INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
  申请人：Boehm Jeffrey Charles

  公开号：US20120040958A1

  公开（公告）日：2012-02-16

  The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  本发明涉及新型吲哚羧酰胺化合物。具体而言，本发明涉及符合式(I)的化合物：其中R1、R2、R3、R4和m的定义如本文所述。本发明的化合物是IKK2的抑制剂，可用于治疗与不适当的IKK2（也称为IKKβ）活性相关的疾病，如类风湿性关节炎、哮喘、鼻炎和COPD（慢性阻塞性肺疾病）。因此，本发明进一步涉及包含本发明化合物的制药组合物。本发明还涉及使用本发明化合物或包含本发明化合物的制药组合物来抑制IKK2活性和治疗与之相关的疾病的方法。
• 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE AND THIAZINE DERIVATIVES AS CETP INHIBITORS
  申请人：Kuo Gee-Hong

  公开号：US20100227857A1

  公开（公告）日：2010-09-09

  The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them.

  本发明涉及一种公式（I）所描述的化合物，其作为CETP抑制剂有用，包含它们的组合物，以及使用它们的方法。
• SUBSTITUTED BENZOCHALCOGENOACENE COMPOUND, THIN FILM COMPRISING THE COMPOUND, AND ORGANIC SEMICONDUCTOR DEVICE INCLUDING THE THIN FILM
  申请人：Miyata Yasuo

  公开号：US20120190868A1

  公开（公告）日：2012-07-26

  Provided are a novel compound suitable as an organic semiconductor material, the compound being a substituted benzochalcogenoacene compound represented by the formula (1), a thin film comprising the compound, and an organic semiconductor device having the thin film as a component. In the formula (1), each E independently represents a sulfur or selenium atom, and R 1 and R 2 each independently represents a hydrogen atom, an optionally substituted C 4-30 alkyl group, an optionally substituted C 4-30 alkoxy group, an optionally substituted C 6-30 aryl group, an optionally substituted C 7-30 aralkyl group, an optionally substituted C 4-30 heteroaryl group, an optionally substituted C 5-30 heteroaralkyl group, or an optionally fluorinated C 3-30 trialkylsilyl group, both R 1 and R 2 being not hydrogen atoms.

  提供了一种新型化合物，适用于有机半导体材料，该化合物是由式（1）表示的取代苯基硫属或硒属芴化合物，还包括该化合物的薄膜以及将该薄膜作为组件的有机半导体器件。在式（1）中，每个E分别表示硫或硒原子，R1和R2各自独立地表示氢原子、可选取代的C4-30烷基、可选取代的C4-30烷氧基、可选取代的C6-30芳基、可选取代的C7-30芳基烷基、可选取代的C4-30杂环芳基、可选取代的C5-30杂环芳基烷基或可选氟化的C3-30三取代硅烷基，R1和R2均不是氢原子。
• Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US11178870B2

  公开（公告）日：2021-11-23

  Pyridine compounds of Formula (1) are provided: wherein R1, R2, X, Y and Het are defined. The pyridine compounds can be used to treat or prevent plant diseases.

  提供了式 (1) 的吡啶化合物： 其中 R1、R2、X、Y 和 Het 已定义。吡啶化合物可用于治疗或预防植物病害。