2-(2',4'-dimethylanilino)quinoline | 1356928-08-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(2',4'-dimethylanilino)quinoline
• 英文别名: N-(2,4-dimethylphenyl)quinolin-2-amine
• CAS: 1356928-08-9
• 化学式: C₁₇H₁₆N₂
• 分子量: 248.327
• InChiKey: AZNYDWXBMDTBLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氯喹啉 、 2,4-二甲基苯胺 以 乙醇 为溶剂， 以77%的产率得到2-(2',4'-dimethylanilino)quinoline
  参考文献：
  名称：

  Synthesis and anti-HCV activity evaluation of anilinoquinoline derivatives

  摘要：

  Hepatitis C virus (HCV) infection is a main cause of chronic liver disease, leading to liver cirrhosis and hepatocellular carcinoma (HCC). The objective of our research was to develop effective agents against viral replication. Here, we have synthesized a series of anilinoquinoline derivatives. Based on a cell-based HCV replicon system, we observed that 2-(3'-nitroanilino)quinoline (18) exhibited anti-HCV activity with a 50% effective concentration (EC50) value of 7 mu M and a selective index (SI) value of 10. In addition, compound 18 possessed the inhibitory effect on HCV NS3/4A protease activity. Therefore, we concluded that the compound 18 possessed a potent activity against HCV replication and could provide as a new lead compound as anti-HCV inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.121

文献信息

• [EN] COMPOSITIONS WITH POLYMERIC OR OLIGOMERIC HYDROXY PHENYL TRIAZINE UV FILTER<br/>[FR] COMPOSITIONS COMPRENANT UN FILTRE UV À BASE D'HYDROXY PHÉNYL TRIAZINE POLYMÈRE OU OLIGOMÈRE
  申请人：BASF SE

  公开号：WO2021064116A1

  公开（公告）日：2021-04-08

  The present invention relates to compositions comprising at least one polymeric or oligomeric hydroxy phenyl triazine UV filter and at least one additional UV filter. Furthermore, the present invention relates to the use of at least one polymeric or oligomeric hydroxy phenyl triazine UV filter for improving the photostability of a sunscreen composition comprising at least one additional UV filter.

  本发明涉及包含至少一种聚合物或寡聚物羟基苯基三嗪紫外线过滤剂和至少一种额外紫外线过滤剂的组合物。此外，本发明还涉及使用至少一种聚合物或寡聚物羟基苯基三嗪紫外线过滤剂来提高含有至少一种额外紫外线过滤剂的防晒霜组合物的光稳定性。
• HIGHLY COMPATIBLE HYDROXYPHENYLTRIAZINE UV-ABSORBERS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1401942A1

  公开（公告）日：2004-03-31
• Highly compatible hydroxyphenyltriazine uv-absorbers
  申请人：——

  公开号：US20040241111A1

  公开（公告）日：2004-12-02

  The present invention relates to highly compatible hydroxyphenyltriazine UV-absorbers and to their use in protecting plants in green houses and the protection of foodstuffs, beverages, pharmaceuticals, cosmetics, personal care products, shampoos and the like from the deleterious effects of ultraviolet radiation. It has been found that certain highly compatible tris-arly-s.triazines are especially effective towards this end when incorporated in the containers or films in which such materials are stored.
• Highly compatible hydroxyphenyltriazine UV-absorbers
  申请人：Lazzari Dario

  公开号：US20070161726A1

  公开（公告）日：2007-07-12

  The present invention relates to highly compatible hydroxyphenyltriazine UV-absorbers and to their use in protecting plants in green houses and the protection of foodstuffs, beverages, pharmaceuticals, cosmetics, personal care products, shampoos and the like from the deleterious effects of ultraviolet radiation. It has been found that certain highly compatible tris-aryl-s-triazines are especially effective towards this end when incorporated in the containers or films in which such materials are stored.
• US3956422A
  申请人：——

  公开号：US3956422A

  公开（公告）日：1976-05-11