Monoisopropylphosphit | 42800-31-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Monoisopropylphosphit
• 英文别名: isopropyl phosphite；monoisopropyl phosphite；Phosphonsaeure-monoisopropylester；i-Propyl-phosphorige Saeure；phosphorous acid monoisopropyl ester；Phosphorigsaeure-monoisopropylester；phosphonic acid monoisopropyl ester；dimethylmethylphosphonate；propan-2-yloxyphosphinic acid
• CAS: 42800-31-7
• 化学式: C₃H₉O₃P
• 分子量: 124.076
• InChiKey: JGFMNFBZRAISGQ-UHFFFAOYSA-N

物化性质

• 沸点：
  183.9±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  7.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  异丙醇 、 Monoisopropylphosphit 在 四磷十氧化物 作用下， 以 1,4-二氧六环 为溶剂， 反应 22.5h， 以45.8%的产率得到亚磷酸二异丙酯
  参考文献：
  名称：

  Method for the esterification of P-O components

  摘要：

  本发明涉及一种新的P-O组分酯化方法。更具体地说，本发明涉及一种新的P-O组分酯化方法，其含有至少一个P-O-H官能团，其中P-O-H官能团被转化为P-O-R官能团。根据本发明的方法可能特别适用于磷酸二酯的制造。

  公开号：

  EP2581378A1
• 作为产物：
  描述：

  亚磷酸二异丙酯 在 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 576.0h， 以60%的产率得到Monoisopropylphosphit
  参考文献：
  名称：

  摘要：

  A P-31 NMR study show that diisopropyl phosphite and benzalaniline do not react with each other as individual components. Adduct formation is made possible by partial hydrolysis of the dialkyl phosphite.

  DOI：

  10.1023/a:1026388315184

文献信息

• Hydrophosphorylation of Alkynes Catalyzed by Palladium: Generality and Mechanism
  作者：Tieqiao Chen、Chang-Qiu Zhao、Li-Biao Han

  DOI：10.1021/jacs.8b00550

  日期：2018.2.28

  H-phosphonates disfavored the addition. For H-phosphinates and secondary phosphine oxides, Pd/dppe/Ph2P(O)OH was the catalyst of choice, which led to highly regioselective formation of the Markovnikov adducts. By using Pd(PPh3)4 as the catalyst, hypophosphinic acid added to terminal alkynes to give the corresponding Markovnikov adducts. Phosphinic acids, phosphonic acid, and its monoester were not applicable

  我们对钯催化的炔烃与 P(O)-H 化合物（即 H-膦酸盐、H-次膦酸盐、仲氧化膦和次膦酸）的一般性、范围、局限性和机理进行了全面研究）。对于 H-膦酸酯，Pd/dppp 是最好的催化剂。具有多种官能团的芳香族和脂肪族炔烃均适用于以高产率和高区域选择性生产马尔可夫尼科夫加合物。芳香族炔烃比脂肪族炔烃显示出更高的反应性。末端炔烃比内部炔烃反应更快。空间拥挤的 H-膦酸盐不喜欢添加。对于 H-次膦酸盐和仲氧化膦，Pd/dppe/Ph2P(O)OH 是首选催化剂，这导致马尔科夫尼科夫加合物的高度区域选择性形成。以Pd(PPh3)4为催化剂，将次膦酸加到末端炔烃上，得到相应的Markovnikov加合物。次膦酸、膦酸及其单酯不适用于这种钯催化的氢磷酸化。机理研究表明，(RO)2P(O)H 与末端炔烃反应，就像布朗斯台德酸一样，通过氢化钯反应选择性地生成 α-烯基钯中间体。另一方面，Ph(RO)P(O)H
• Extraction of polysaccharides from bran with phosphonate or phosphinate-derived ionic liquids under short mixing time and low temperature
  作者：Mitsuru Abe、Yukinobu Fukaya、Hiroyuki Ohno

  DOI：10.1039/c003976d

  日期：——

  A novel series of 1-alkyl-3-methylimidazolium phosphonate and phosphinate-type ionic liquids is able to extract polysaccharides from bran, which is a renewable biomass. In particular, 1-ethyl-3-methylimidazolium phosphinate is a novel low viscosity polar ionic liquid with which one can extract a series of polysaccharides from bran without heating. The physico-chemical properties of a series of these salts are also determined, in a study of the ability of these ionic liquids to extract cellulose and other polysaccharides from bran.

  一系列新型 1-烷基-3-甲基咪唑鎓膦酸盐和膦酸盐型离子液体能够从可再生生物质麸皮中提取多糖。其中，1-乙基-3-甲基咪唑鎓膦酸盐是一种新型的低粘度极性离子液体，无需加热即可从麦麸中提取一系列多糖。在研究这些离子液体从麸皮中提取纤维素和其他多糖的能力时，还确定了一系列这些盐的物理化学性质。
• Novel prostanoic acid derivatives and process for the preparation thereof
  申请人：Schering Aktiengesellschaft

  公开号：US04004020A1

  公开（公告）日：1977-01-18

  Prostaglandins of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, carboxy, aryloxycarbonyl, alkoxycarbonyl of 1-8 carbon atoms in the alkoxy group, or the group -COO-CH.sub.2 -U-V wherein U is a direct C-C bond, carbonyl or carbonyloxy and V is phenyl substituted by phenyl, alkoxy of 1-2 carbon atoms or halogen; R.sub.2 is hydroxy and R.sub.3 is a hydrogen atom or R.sub.2 and R.sub.3 collectively are an oxygen atom; A is -CH.sub.2 -CH.sub.2 or trans-CH=CH; B is -CH.sub.2 -CH.sub.2 or CH=CH; one of R.sub.4 and R.sub.5 is hydroxy and the other is a hydrogen atom; R.sub.6 and R.sub.7 each are alkyl of 1-10 carbon atoms or collectively are alkylene of up to 7 carbon atoms and with 2-3 carbon atoms in the chain, phenylene or naphthylene; R.sub.8 is a hydrogen atom or alkyl of 1-5 carbon atoms; ##STR2## when R.sub.2 is hydroxy and R.sub.3 is a hydrogen atom or is ##STR3## or -CH=CH- when R.sub.2 and R.sub.3 collectively are an oxygen atom; or, when R.sub.1 is carboxy, a physiologically acceptable salt thereof with a base, possess the activity of the corresponding natural prostaglandins, including a luteolytic effect, and are useful in triggering abortions and syncronizing the conception cycle of mammals.

  公式为##STR1##的前列腺素，其中R.sub.1是羟甲基，羧基，芳基氧羰基，1-8个碳原子的烷氧羰基或基团-COO-CH.sub.2-U-V，其中U是直接的C-C键，羰基或羰氧基，V是苯基，被苯基，1-2个碳原子的烷氧基或卤素取代; R.sub.2是羟基，R.sub.3是氢原子或R.sub.2和R.sub.3共同是氧原子; A是-CH.sub.2-CH.sub.2或trans-CH=CH; B是-CH.sub.2-CH.sub.2或CH=CH; R.sub.4和R.sub.5中的一个是羟基，另一个是氢原子; R.sub.6和R.sub.7各自是1-10个碳原子的烷基，或共同是碳链中有2-3个碳原子，苯基或萘基的烷基; R.sub.8是氢原子或1-5个碳原子的烷基; ##STR2##当R.sub.2是羟基，R.sub.3是氢原子或是##STR3##或-CH=CH-当R.sub.2和R.sub.3
• Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
  申请人：Laboratori Baldacci SpA

  公开号：US06242433B1

  公开（公告）日：2001-06-05

  The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process of preparation thereof.

  本发明涉及一种新型的戊二十烯基衍生物及其药学上可接受的盐，具有对真核细胞的抗增殖活性，可抑制蛋白质戊二十烷基化。本发明还涉及包含该新型衍生物的药物组合物以及其制备方法。
• Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair
  作者：Lingqi Qiu、R. Graham Cooks

  DOI：10.1002/anie.202210765

  日期：2022.10.10

  Spontaneous oxidation and reduction of phosphonate occur simultaneously in microdroplets. The key active species are the endogenous water radical cation and anion derived from water molecules and present at the droplet surface.

  膦酸盐的自发氧化和还原在微滴中同时发生。关键的活性物质是源自水分子并存在于液滴表面的内源性水自由基阳离子和阴离子。