2-(4'-bromophenyl)-1-(4a-methylphenyl)-4,5-dimethyl-1H-imidazole | 1239580-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4'-bromophenyl)-1-(4a-methylphenyl)-4,5-dimethyl-1H-imidazole
• 英文别名: 2-(4-Bromophenyl)-4,5-dimethyl-1-(4-methylphenyl)imidazole；2-(4-bromophenyl)-4,5-dimethyl-1-(4-methylphenyl)imidazole
• CAS: 1239580-12-1
• 化学式: C₁₈H₁₇BrN₂
• 分子量: 341.25
• InChiKey: QKYDDLNGJVKDLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烷,三氯氟- 、 对溴苯甲醛 、 2,3-丁二酮 在 ammonium acetate 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 以68%的产率得到2-(4'-bromophenyl)-1-(4a-methylphenyl)-4,5-dimethyl-1H-imidazole
  参考文献：
  名称：

  Room temperature synthesis of tri-, tetrasubstituted imidazoles and bis-analogues by mercaptopropylsilica (MPS) in aqueous methanol: application to the synthesis of the drug trifenagrel

  摘要：

  The heterogeneous solid catalyst, mercaptopropylsilica (MPS), has been prepared by a modified procedure in water and its structure confirmed by solid state carbon-13 CP-MAS NMR spectrum. This catalyst has been efficiently utilized for the synthesis of a wide variety of tri-, tetrasubstituted imidazoles and their bis-analogues at room temperature. The protocol was further explored for the synthesis of the drug trifenagrel. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.102

文献信息

• Room temperature synthesis of tri-, tetrasubstituted imidazoles and bis-analogues by mercaptopropylsilica (MPS) in aqueous methanol: application to the synthesis of the drug trifenagrel
  作者：Chhanda Mukhopadhyay、Pradip Kumar Tapaswi、Michael G.B. Drew

  DOI：10.1016/j.tetlet.2010.05.102

  日期：2010.7

  The heterogeneous solid catalyst, mercaptopropylsilica (MPS), has been prepared by a modified procedure in water and its structure confirmed by solid state carbon-13 CP-MAS NMR spectrum. This catalyst has been efficiently utilized for the synthesis of a wide variety of tri-, tetrasubstituted imidazoles and their bis-analogues at room temperature. The protocol was further explored for the synthesis of the drug trifenagrel. (C) 2010 Elsevier Ltd. All rights reserved.