perfluoro-4-heptanol | 378-89-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: perfluoro-4-heptanol
• 英文别名: di-(perfluoro n-propyl) methanol；4H-tetradecafluoro-heptan-4-ol；4H-Tetradecafluor-heptan-4-ol；1,1,1,2,2,3,3,5,5,6,6,7,7,7-Tetradecafluoroheptan-4-ol
• CAS: 378-89-2
• 化学式: C₇H₂F₁₄O
• 分子量: 368.07
• InChiKey: SMNMMURVJITEJC-UHFFFAOYSA-N

物化性质

• 沸点：
  58 °C(Press: 78 Torr)
• 密度：
  1.6735 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  perfluoro-4-heptanol 、 氯甲基甲基醚 在 sodium hydride 作用下， 以 乙醚 为溶剂， 反应 1.08h， 以40%的产率得到4H-perfluoro-4-heptyl methoxymethyl ether
  参考文献：
  名称：

  Perfluorinated Cyclic and Acyclic Keto−Enol Systems:  A Remarkable Contrast

  摘要：

  Recent reports from this laboratory have revealed that highly fluorinated 4- and 5-membered-ring enols are comparable in stability to, or more stable thermodynamically than, the corresponding ketones, even in non-Lewis-basic media. Work on perfluorinated keto-enol systems has now been extended to 2H-perfluorocyclohexanone plus its enol and to a series of acyclic analogues. In carbon tetrachloride, K-E/K = 0.33 (22 degrees C) for the six-ring system, but only enol is detectable in Lewis-basic solvents. This shift is attributable to strong hydrogen-bond formation between the enol and Lewis base. A perfluoroenol has been shown to form significantly stronger hydrogen bonds than the potent hexafluoroisopropyl alcohol. Acyclic systems (e.g., 3H-perfluoro-2-butanone and its enol) contrast sharply with the cyclic, as no enol is detectable at equilibrium even in powerfully Lewis-basic media. Ab initio quantum mechanical calculations indicate that it is principally the enols, not the ketones, that are responsible for the difference between the two types of keto-enol systems, i.e. acyclic perfluoroenols are strongly destabilized relative to cyclic counterparts.

  DOI：

  10.1021/ja963788n
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 作用下， 生成 perfluoro-4-heptanol
  参考文献：
  名称：

  Reactions of Perfluorinated Propylmagnesium Iodide

  摘要：

  DOI：

  10.1021/ja01100a510

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.4, 2.2.4, page 68 - 115
  作者：

  DOI：——

  日期：——
• Haszeldine, R. N., Journal of the Chemical Society
  作者：Haszeldine, R. N.

  DOI：——

  日期：——
• A model of therapeutic intervention with Indigenous Australians
  作者：David Vicary、Henry Andrews

  DOI：10.1111/j.1467-842x.2001.tb00592.x

  日期：2001.8

  Many non-Aboriginal mental health practitioners are confronted by the lack of practical information pertaining to interventions with Aboriginal clientele. Subsequently, this may have engendered uncertainty in potential therapists and counsellors due to the lack of reliable, practical and culturally appropriate information. Those non-Aboriginal mental health practitioners working in the field with Aboriginal clients do so with varying degrees of success and build upon their knowledge base through personal experience and anecdotal information. Unfortunately, this information is often not made available to others working in the field through journal publication. This Practice Note examines a model of intervention aimed at developing relationships to enhance therapeutic interventions at the individual, family and systems level. As a way of clarification, the model is described via a case study involving a psychological intervention with a remote Aboriginal community.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.4, 1.3.3.8, page 33 - 59
  作者：

  DOI：——

  日期：——
• Preparation and Some Reactions of n-Hepta-fluoropropylmagnesium Iodide
  作者：O. R. Pierce、M. Levine

  DOI：10.1021/ja01101a515

  日期：1953.3