1-(3-(1,2,2-trifluorovinyl)phenyl)ethanone | 1403353-81-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-(1,2,2-trifluorovinyl)phenyl)ethanone
• 英文别名: 1-[3-(1,2,2-Trifluoroethenyl)phenyl]ethanone；1-[3-(1,2,2-trifluoroethenyl)phenyl]ethanone
• CAS: 1403353-81-0
• 化学式: C₁₀H₇F₃O
• 分子量: 200.16
• InChiKey: OLWLOMXCMGUVOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三氟氯乙烯 、 3-乙酰基苯硼酸 在 potassium phosphate 、 tri-tert-butylphosphonium tetrafluoroborate 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 2.0h， 以82%的产率得到1-(3-(1,2,2-trifluorovinyl)phenyl)ethanone
  参考文献：
  名称：

  Preparation of Trifluorostyrenes via Palladium-Catalyzed Coupling of Arylboronic Acids with Chloro- and Bromotrifluoroethylene

  摘要：

  A highly efficient and cost-effective method for the preparation of alpha,beta,beta-trifluorostyrene (TFS) and its derivatives is described. The method required only 0.2 mol % of Pd(dba)(2) and 0.4 mol % of (PBu3)-Bu-t and occurred to full conversion within 2.0 h. With this method, a wide range of arylboronic acids were efficiently incorporated to generate alpha,beta,beta-trifluorostyrene derivatives.

  DOI：

  10.1021/jo301998g

文献信息

• Preparation of Trifluorostyrenes via Palladium-Catalyzed Coupling of Arylboronic Acids with Chloro- and Bromotrifluoroethylene
  作者：Chunfa Xu、Sheng Chen、Long Lu、Qilong Shen

  DOI：10.1021/jo301998g

  日期：2012.11.16

  A highly efficient and cost-effective method for the preparation of alpha,beta,beta-trifluorostyrene (TFS) and its derivatives is described. The method required only 0.2 mol % of Pd(dba)(2) and 0.4 mol % of (PBu3)-Bu-t and occurred to full conversion within 2.0 h. With this method, a wide range of arylboronic acids were efficiently incorporated to generate alpha,beta,beta-trifluorostyrene derivatives.