3-phenoxy-1H-pyridin-2-one | 32967-13-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-phenoxy-1H-pyridin-2-one
• 英文别名: 3-phenoxy-2-pyridone；3-Phenoxy-2-<1H>-pyridon；3-Phenoxy-2-pyridon；3-phenoxy-1H-pyridin-2-one
• CAS: 32967-13-8
• 化学式: C₁₁H₉NO₂
• 分子量: 187.198
• InChiKey: RLGXNFIGSANNQD-UHFFFAOYSA-N

物化性质

• 熔点：
  159-160 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  387.2±42.0 °C(Predicted)
• 密度：
  1.223±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-phenoxy-1H-pyridin-2-one 以59%的产率得到
  参考文献：
  名称：

  VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. , 1975, 18, NO 1, 1-8

  摘要：

  DOI：
• 作为产物：
  描述：

  3-oxo-2-phenoxybutanamide 、 1,1,3,3-四甲氧基丙烷 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 4.5h， 生成 3-phenoxy-1H-pyridin-2-one
  参考文献：
  名称：

  PROCESS FOR PRODUCTION OF PHENOXY-SUBSTITUTED 2-PYRIDONE COMPOUNDS

  摘要：

  公开号：

  EP1538145B1

文献信息

• Diphenyl ether antimicrobial compounds
  申请人：Tonge J. Peter

  公开号：US20060041025A1

  公开（公告）日：2006-02-23

  The present invention is directed to compounds having the formula: wherein A 1 , A 3 , A 6 , and A 8 independently represent CH or N; A 2 represents N or C—X 1 a —R 1 ; A 4 represents N or C—X 2 b —R 2 ; R 1 and R 2 independently represent H, or a hydrocarbon containing a minimum of one carbon atom and a maximum of twenty six carbon atoms, wherein the hydrocarbon is unsubstituted, or is substituted with one or more of —OH, —NH 2 , —SH, halo, or —COOH; X 1 and X 2 independently represent —O—, —S—, —NH—, —C(O)O—, —C(O)—, —C(O)NH—, or —SO 2 NH—; a and b independently represent 0 or 1, provided that when a and b are both 0, then R 1 and R 2 are not both H; when a is 1, then R 1 is not H; and when b is 1, then R 2 is not H; A 5 and A 9 independently represent CR 3 or N; R 3 represents H, methyl, ethyl, or halo; A 7 represents CR 4 or N; R 4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted with halo, nitro, hydroxy, amino, or amido; provided that A 2 and A 4 are not both N; and not more than three of A 5 , A 6 , A 7 , A 8 , and A 9 are N. The invention is also directed to pharmaceutical compositions comprising a compound according to (1) and a pharmaceutically acceptable carrier. The invention is also directed to methods of inhibiting the growth of a bacterium containing an enoyl reductase enzyme encoded by a fabI gene, a fabK gene, a fabL gene, or a combination thereof, in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a compound according to formula (1).

  本发明涉及具有以下式的化合物：其中A1、A3、A6和A8独立地表示CH或N；A2表示N或C-X1a-R1；A4表示N或C-X2b-R2；R1和R2独立地表示H，或含有至少一个碳原子和最多二十六个碳原子的碳氢化合物，其中该碳氢化合物未经取代或用一种或多种-OH、NH2、SH、卤素或-COOH取代；X1和X2独立地表示-O-、-S-、-NH-、-C（O）O-、-C（O）-、-C（O）NH-或-SO2NH-；a和b独立地表示0或1，但当a和b都为0时，R1和R2不同时为H；当a为1时，R1不为H；当b为1时，R2不为H；A5和A9独立地表示CR3或N；R3表示H、甲基、乙基或卤素；A7表示CR4或N；R4表示H、甲基、乙基、卤素、硝基、羟基、氨基、酰胺基或用卤素、硝基、羟基、氨基或酰胺基取代的甲基或乙基基团；其中A2和A4不同时为N；且A5、A6、A7、A8和A9中不超过三个为N。本发明还涉及包含式（1）的化合物和药学上可接受的载体的制药组合物。本发明还涉及一种抑制哺乳动物中编码fabI基因、fabK基因、fabL基因或其组合的烯醇还原酶酶的细菌的生长的方法，该方法包括向哺乳动物中施加有效量的符合式（1）的化合物。
• Fluoride-Releasing Compositions
  申请人：Xu Xiaoming

  公开号：US20120264939A1

  公开（公告）日：2012-10-18

  Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.

  本发明公开了可用于制备牙科复合修复材料、牙科粘接剂或其他牙科材料的螯合单体和释放氟化物组合物，以产生具有高氟释放速率和高氟充电能力的材料。这种牙科修复材料可以帮助减少患者的龋齿水平，特别是减少在修复材料边缘发生的龋齿水平。
• Process for production of phenoxy-substituted 2-pyridone compounds
  申请人：Furukawa Takashi

  公开号：US20050154210A1

  公开（公告）日：2005-07-14

  3-Phenoxy-2-pyridone compound can be produced by making the amide compound of the formula (1): wherein R is optionally substituted phenyl; react with a malonoaldehyde derivative such as 3-alkoxypropenal and the like in the presence of a protonic acid.
• US4491585A
  申请人：——

  公开号：US4491585A

  公开（公告）日：1985-01-01
• US4529557A
  申请人：——

  公开号：US4529557A

  公开（公告）日：1985-07-16