4-(3-hydroxypropoxy)butan-1-ol | 123170-64-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3-hydroxypropoxy)butan-1-ol
• CAS: 123170-64-9
• 化学式: C₇H₁₆O₃
• 分子量: 148.202
• InChiKey: PMQVYMYYAIMSRP-UHFFFAOYSA-N

物化性质

• 沸点：
  278.3±20.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-hydroxypropoxy)butan-1-ol 、 三甲基氯硅烷 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 1-trimethylsilanyloxy-4-(3-trimethylsilanyloxy-propoxy)-butane
  参考文献：
  名称：

  Thermotropic Behavior of a Liquid Crystalline Polybibenzoate with an Asymmetric Oxymethylenic Spacer

  摘要：

  The thermotropic phase behavior of P3O4B, a polybibenzoate with an asymmetric oxymethylenic spacer, has been analyzed by DSC, real-time synchrotron X-ray diffraction, and optical microscopy. The results show that the following phases are found on cooling: isotropic melt, SA mesophase, Sc mesophase, and three-dimensional crystal. The subsequent melting reveals the enantiotropic character of P3O4B since the inverse phase sequence is found. Additionally, a clear recrystallization process is observed on melting, prior to the crystal-Sc transition. The thermotropic properties of P3O4B are compared with those of its analogue polyester with an all-methylene spacer, poly(octamethylene p,p'bibenzoate), P8MB, and other polybibenzoates with oxymethylenic spacers. Compared with P8MB, significantly lower transition temperatures are found for P3O4B due to the higher flexibility and asymmetry of the spacer. The lowering is especially important for the formation of the final crystal structure, so that the mesophase temperature window is considerably enlarged in P3O4B, allowing to observe the transition S-A to S-C. Moreover, the comparison of the thermotropic properties of P3O4B with those of other polybibenzoates with oxymethylenic spacers reveals that P3O4B is the only one able to crystallize at the usual cooling rates of the calorimeter.

  DOI：

  10.1021/ma048458z
• 作为产物：
  描述：

  1-trimethylsilanyloxy-4-(3-trimethylsilanyloxy-propoxy)-butane 在 水 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 4-(3-hydroxypropoxy)butan-1-ol
  参考文献：
  名称：

  Thermotropic Behavior of a Liquid Crystalline Polybibenzoate with an Asymmetric Oxymethylenic Spacer

  摘要：

  The thermotropic phase behavior of P3O4B, a polybibenzoate with an asymmetric oxymethylenic spacer, has been analyzed by DSC, real-time synchrotron X-ray diffraction, and optical microscopy. The results show that the following phases are found on cooling: isotropic melt, SA mesophase, Sc mesophase, and three-dimensional crystal. The subsequent melting reveals the enantiotropic character of P3O4B since the inverse phase sequence is found. Additionally, a clear recrystallization process is observed on melting, prior to the crystal-Sc transition. The thermotropic properties of P3O4B are compared with those of its analogue polyester with an all-methylene spacer, poly(octamethylene p,p'bibenzoate), P8MB, and other polybibenzoates with oxymethylenic spacers. Compared with P8MB, significantly lower transition temperatures are found for P3O4B due to the higher flexibility and asymmetry of the spacer. The lowering is especially important for the formation of the final crystal structure, so that the mesophase temperature window is considerably enlarged in P3O4B, allowing to observe the transition S-A to S-C. Moreover, the comparison of the thermotropic properties of P3O4B with those of other polybibenzoates with oxymethylenic spacers reveals that P3O4B is the only one able to crystallize at the usual cooling rates of the calorimeter.

  DOI：

  10.1021/ma048458z

文献信息

• Thiophenazofarbstoffe mit einer Kupplungskomponente auf Basis von m-Phenylendiamin
  申请人：BASF Aktiengesellschaft

  公开号：EP0381974A2

  公开（公告）日：1990-08-16

  Thiophenazofarbstoffe der Formel in der X Cyano oder C₁-C₄-Alkoxycarbonyl, Y Halogen, Hydroxy, Mercapto, gegebenenfalls substituiertes C₁-C₆-­Alkoxy, C₅-C₇-Cycloalkoxy, gegebenenfalls substituiertes Phenoxy, gegebenenfalls substituiertes C₁-C₆-Alkylthio, C₅-C₇-Cycloalkylthio, gegebenenfalls substituiertes Phenylthio, C₁-C₆-Alkylsulfonyl oder gegebenenfalls substituiertes Phenylsulfonyl, Z Nitro, Cyano, C₁-C₄-Alkanoyl, Benzoyl, C₁-C₄-Alkylsulfonyl, Phenyl­sulfonyl oder einen Rest der Formel -CH=CB¹B² oder -CH=N-B³, wobei B¹ und B² unabhängig voneinander für Cyano, gegebenenfalls substituiertes C₁-C₆-Alkoxycarbonyl oder C₃-C₆-Alkenyloxycarbonyl oder ein Rest B¹ oder B² für Cyano und der andere für C₁-C₄-Alkylsulfonyl, gegebenen­falls substituiertes Phenyl, Benzoyl, Phenylsulfonyl oder Carbamoyl und B³ für Hydroxy, C₁-C₄-Alkoxy, Phenoxy oder Phenylamino stehen, R¹ C₁-C₄-Alkoxy, R² Wasserstoff, gegebenenfalls substituiertes C₁-C₁₀-Alkyl oder R³, R³ einen Rest der Formel CH₂-CH(OR⁵)-CH₂R⁶ und R⁴ gegebenenfalls substituiertes C₁-C₆-Alkanoylamino oder gegebenenfalls substituiertes Benzoylamino bedeuten, wobei R⁵ für Wasserstoff, C₁-C₁₀-Alkanoyl, C₁-C₁₀-Alkoxycarbonyl oder C₁-C₁₀-Mono- oder Dialkylcarbamoyl, wobei die Alkylgruppen der genannten Substituenten durch Sauerstoffatome unterbrochen sein können, und R⁶ für Chlor, Brom oder gegebenenfalls substituiertes Hydroxy stehen, und ihre Verwendung zum Färben von textilen Fasern.

  式中的噻吩并染料 其中 X 氰基或 C₁-C₄- 烷氧基羰基、 Y 卤素、羟基、巯基、任选取代的 C₁-C₆- 烷氧基、C₅-C₇-环烷氧基、任选取代的苯氧基、任选取代的 C₁-C₆- 烷硫基、C₅-C₇-环烷基硫代、任选取代的苯基硫代、C₁-C₆-烷基磺酰基或任选取代的苯基磺酰基、 Z 是硝基、氰基、C₁-C₄-烷酰基、苯甲酰基、C₁-C₄-烷基磺酰基、苯基磺酰基或式 -CH=CB¹B² 或 -CH=N-B³的基团，其中 B¹ 和 B² 相互独立地是氰基、任选取代的 C₁-C₆-烷氧基羰基或 C₃-C₆-烯氧基羰基，或一个基团 B¹ 或 B² 为氰基，另一个基团为 C₁-C₄-烷基磺酰基、B³代表羟基、C₁-C₄-烷氧基、苯氧基或苯基氨基、 R¹ 是 C₁-C₄-烷氧基、 R² 是氢、任选取代的 C₁-C₁₀ 烷基或 R³、 R³ 是式 CH₂-CH(OR⁵)-CH₂R⁶ 的基团，且 R⁴ 是任选取代的 C₁-C₆-alkanoylamino 或任选取代的苯甲酰氨基，其中 R⁵ 是氢、C₁-C₁₀-烷酰基、C₁-C₁₀-烷氧基羰基或 C₁-C₁₀-单烷基或二烷基氨基甲酰基，上述取代基的烷基有可能被氧原子打断，以及 R⁶ 代表氯、溴或任选取代的羟基、 以及它们在纺织纤维染色中的用途。
• PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP3666766A1

  公开（公告）日：2020-06-17

  The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:

  本发明提供了一种由下式[I]代表的化合物或其药学上可接受的盐，对 20-HETE 生成酶具有抑制作用。 (上式[I]中，下式[II]所代表的结构： 代表下式组[III]所代表的任何一种结构： R1、R2、R3 和 R4 独立地代表氢原子、氟原子、甲基或类似物、 R5 代表式组 [IV] 所代表的任何一种结构：
• Fluorescent naphthalene -1,4,5,8-tetracarboxylic bisimides with an electron-donating substituent on the nucleus
  申请人：——

  公开号：US20030153005A1

  公开（公告）日：2003-08-14

  Naphthalene-1,4,5,8-tetracarboxylic bisimides of the general formula I 1 where the variables are defined as follows: R 1 and R 2 independently of one another are hydrogen, substituted or unsubstituted alkyl or substituted or unsubstituted aryl; X and Y independently of one another are halogen, amino or a radical with the formula —NHR 3 , —OR 3 , where R 3 has the formula —CH 2 R 4 , —CHR 4 R 5 , or —CR 4 R 5 R 6 , where R 4 , R 5 , and R 6 independently of one another are hydrogen, substituted or unsubstituted alkyl, aryl, alkoxy, alkylthio, aryloxy or arylthio, and at least one of the two substituents X and Y is other than halogen, their preparation and use as fluorescent dyes, for coloring high molecular mass organic materials and inorganic materials, as laser dyes, and also for fluorescence marking and as fluorescent labels for biomolecules.
• US4543404A
  申请人：——

  公开号：US4543404A

  公开（公告）日：1985-09-24
• US5145952A
  申请人：——

  公开号：US5145952A

  公开（公告）日：1992-09-08