(7-methylindolizine-1,2,3-triyl)tris((4-bromophenyl)methanone) | 1352441-18-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (7-methylindolizine-1,2,3-triyl)tris((4-bromophenyl)methanone)
• 英文别名: [2,3-Bis(4-bromobenzoyl)-7-methylindolizin-1-yl]-(4-bromophenyl)methanone；[2,3-bis(4-bromobenzoyl)-7-methylindolizin-1-yl]-(4-bromophenyl)methanone
• CAS: 1352441-18-9
• 化学式: C₃₀H₁₈Br₃NO₃
• 分子量: 680.19
• InChiKey: XUEYXOKNFHINGF-UHFFFAOYSA-N

物化性质

• 熔点：
  215-216 °C
• 密度：
  1.65±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲基吡啶 、 2,4'-二溴苯乙酮 在 哌啶 、 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以40%的产率得到(7-methylindolizine-1,2,3-triyl)tris((4-bromophenyl)methanone)
  参考文献：
  名称：

  One-pot multicomponent synthesis of polysubstituted indolizines

  摘要：

  Concise and efficient four-component tandem approaches to polysubstituted indolizines have been developed under metal-free and mild aerobic conditions in refluxing acetonitrile. The mechanism of the novel reactions was proposed involving the formation of pyridinium ylides and alpha,beta-unsaturated ketones with subsequent 1,3-dipolar cycloaddition and aromatization reaction. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.10.083

文献信息

• One-pot multicomponent synthesis of polysubstituted indolizines
  作者：Zhenjun Mao、Xuejian Li、Xufeng Lin、Ping Lu、Yanguang Wang

  DOI：10.1016/j.tet.2011.10.083

  日期：2012.1

  Concise and efficient four-component tandem approaches to polysubstituted indolizines have been developed under metal-free and mild aerobic conditions in refluxing acetonitrile. The mechanism of the novel reactions was proposed involving the formation of pyridinium ylides and alpha,beta-unsaturated ketones with subsequent 1,3-dipolar cycloaddition and aromatization reaction. (C) 2011 Elsevier Ltd. All rights reserved.