(4,5-diphenyl-1H-imidazol-2-yl)(4-fluorophenyl)methanone | 1523487-67-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4,5-diphenyl-1H-imidazol-2-yl)(4-fluorophenyl)methanone
• 英文别名: (4,5-diphenyl-1H-imidazol-2-yl)-(4-fluorophenyl)methanone
• CAS: 1523487-67-3
• 化学式: C₂₂H₁₅FN₂O
• 分子量: 342.372
• InChiKey: MNEICANUBLNBOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟苯乙酮 、 安息香精油 在 ammonium acetate 、 碘 、 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以65%的产率得到(4,5-diphenyl-1H-imidazol-2-yl)(4-fluorophenyl)methanone
  参考文献：
  名称：

  Synthesis of trisubstituted imidazoles via a convergent reaction network from methyl ketones and benzoins

  摘要：

  A novel method for constructing trisubstituted imidazoles has been created using simple and readily available aromatic ketones, benzoins, and ammonium acetate as starting materials. The new synthetic strategy utilized a convergent integration of two self-labor domino sequences, providing a typical example for logical self-organization synthesis. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.080

文献信息

• Synthesis of trisubstituted imidazoles via a convergent reaction network from methyl ketones and benzoins
  作者：Wei-Jian Xue、Hong-Zheng Li、Fang-Fang Gao、Anxin Wu

  DOI：10.1016/j.tet.2013.11.080

  日期：2014.1

  A novel method for constructing trisubstituted imidazoles has been created using simple and readily available aromatic ketones, benzoins, and ammonium acetate as starting materials. The new synthetic strategy utilized a convergent integration of two self-labor domino sequences, providing a typical example for logical self-organization synthesis. (C) 2013 Elsevier Ltd. All rights reserved.