hexapropyleneglycol | 55333-98-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: hexapropyleneglycol
• 英文别名: hexa-1,3-propyleneglycol；1,3-propanediol hexamer；4,8,12,16,20-pentaoxa-tricosane-1,23-diol；3,3'-(4,8,12-trioxa-pentadecane-1,15-diyldioxy)-bis-propan-1-ol；4.8.12.16.20-Pentaoxa-1.23-tricosandiol；3-[3-[3-[3-[3-(3-Hydroxypropoxy)propoxy]propoxy]propoxy]propoxy]propan-1-ol
• CAS: 55333-98-7
• 化学式: C₁₈H₃₈O₇
• 分子量: 366.496
• InChiKey: POUOCTVICRHRGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  25
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  hexapropyleneglycol 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到hexapropylene glycol bis-mesylate
  参考文献：
  名称：

  Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities

  摘要：

  Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ER alpha dimers as a template. The syntheses of several 17 alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERa and ER beta were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.016
• 作为产物：
  描述：

  dibenzyl hexapropyleneglycol 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以81%的产率得到hexapropyleneglycol
  参考文献：
  名称：

  Preparation of Discrete Oligoethers:  Synthesis of Pentabutylene Glycol and Hexapropylene Glycol by Two Complementary Methods

  摘要：

  Two experimentally facile methods for the preparation of discrete oligoethers are reported. The first involves an iterative sequence of oxidation, acetal formation, and reductive ring opening for the synthesis of penta-1,4-butylene glycol. The second method is also iterative, comprising phase-transfer etherification and end-group deprotection to form hexa-1,3-propylene glycol. These methods offer significantly improved yields and purification protocols over previously reported syntheses.

  DOI：

  10.1021/jo034728k

文献信息

• ANTIMICROBIAL COMPOSITIONS COMPRISING TRIMETHYLENE GLYCOL OLIGOMER AND METHODS OF USING THE COMPOSITIONS
  申请人：Fenyvesi Gyorgyi

  公开号：US20110224307A1

  公开（公告）日：2011-09-15

  Disclosed are antimicrobial compositions, and methods for killing, inhibiting, or preventing the growth of microbes, using trimethylene glycol oligomers or dimers. The trimethylene glycol oligomers and dimers have the formula R(CH 2 CH 2 CH 2 —O—CH 2 CH 2 CH 2 ) n R 1 where R and R 1 are hydroxyl, amine, or ester functionalitiess, and n is 2 or higher. The antimicrobial compositions are useful in personal care and cosmetic compositions

  本发明涉及抗微生物组合物，以及使用三亚甲基二醇低聚物或二聚物杀灭、抑制或防止微生物生长的方法。所述三亚甲基二醇低聚物和二聚物的化学式为R(CH2CH2CH2—O—CH2CH2CH2)nR1，其中R和R1是羟基、胺基或酯基官能团，n为2或更高。所述抗微生物组合物适用于个人护理和化妆品组合物。
• High-dilution cyclization of polyoxapentacosanodinitriles
  作者：Melvin S. Newman、Taylor G. Barbee、C. Newton Blakesley、Zia-ud-Din、Stanley Gromelski、V. K. Khanna、Len-Fang Lee、J. Radhakrishnan、Roger L. Robey

  DOI：10.1021/jo00908a003

  日期：1975.10
• [EN] AQUEOUS PIGMENT DISPERSION CONTAINING LOW MOLECULAR WEIGHT POLYTRIMETHYLENE ETHER GLYCOL<br/>[FR] DISPERSION AQUEUSE DE PIGMENT CONTENANT DU POLYTRIMÉTHYLÈNE ÉTHER GLYCOL DE FAIBLE MASSE MOLÉCULAIRE
  申请人：DU PONT

  公开号：WO2013028640A3

  公开（公告）日：2013-05-02
• NEWMAN M. S; BARBEE JR. T. G.; BLAKESLEY C. N.; DIN Z. UD; GROMELSKI JR. +, J. ORG. CHEM. <JOCE-AH>, 1975, 40, NO 20, 2863-2870
  作者：NEWMAN M. S、 BARBEE JR. T. G.、 BLAKESLEY C. N.、 DIN Z. UD、 GROMELSKI JR. +

  DOI：——

  日期：——
• Voc Free Coatings Strippers
  申请人：Sugerman Gerald

  公开号：US20070261720A1

  公开（公告）日：2007-11-15

  Utilization of certain essentially nonvolatile oligo alkylene glycols and or their mono alkyl ethers, and/or hydroxy esters thereof, in combination with selected, optionally (partially) neutralized, nonvolatile hydroxyl group bearing di/oligoamines, optionally in conjunction with defoamers, water, and/or wetting agents, have been found to produce VOC free, minimally corrosive, highly efficient strippers for coatings, such as paints, printing inks, and floor waxes.