3-(2-bromo)ethyloxy-4-methylthiophene | 187029-81-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-bromo)ethyloxy-4-methylthiophene
• 英文别名: 3-(2'-bromoethoxy)-4-methylthiophene；3-(2-bromoethoxy)-4-methylthiophene；3-(2-bromo)ethoxy-4-methylthiophene
• CAS: 187029-81-8
• 化学式: C₇H₉BrOS
• 分子量: 221.118
• InChiKey: BDEQZKWUAZYJOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  260.5±30.0 °C(Predicted)
• 密度：
  1.485±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-bromo)ethyloxy-4-methylthiophene 在 sodium sulfite 作用下， 以 丙酮 为溶剂， 以60%的产率得到Sodium; 2-(4-methyl-thiophen-3-yloxy)-ethanesulfonate
  参考文献：
  名称：

  Functionalized regioregular polythiophenes: towards the development of biochromic sensors

  摘要：

  Biochromic polythiophenes have been synthesized and the interaction of avidin with the biotinylated water-soluble polymers results in stunning chromic effects, opening the way to the detection of numerous biological components.

  DOI：

  10.1039/cc9960002761
• 作为产物：
  描述：

  3-溴-4-甲基噻吩 以 N-甲基吡咯烷酮 、 甲醇 、 甲苯 为溶剂， 生成 3-(2-bromo)ethyloxy-4-methylthiophene
  参考文献：
  名称：

  Spectral response of a methylimidazolium-functionalized polythiophene to phosphates

  摘要：

  We report on the colorimetric and fluorimetric responses of the cationic water-soluble polythiophene derivative poly[3-(2-(N-(N'-methylimidazole))ethoxy)-4-methylthiophene] in presence of different phosphates with a focus on ATP. UV/Vis absorbance and fluorescence measurements show that ATP concentrations can be determined in aqueous solutions with a sufficient selectivity to other phosphates. Measurements of circular dichroism reveal that the polymer forms a random coil structure that exhibits no signal in the CD spectrum. Upon addition of ATP the conformation changes to a helix, yielding in strong CD peaks. These experimental data suggest that this polymer is an attractive, simple and versatile colorimetric and fluorimetric probe for nucleoside triphosphates such as ATP. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2012.04.012

文献信息

• Self-acid-doped highly conducting polythiophenes
  申请人：Universitede Montreal

  公开号：US06051679A1

  公开（公告）日：2000-04-18

  The invention relates to thiophenes bearing (.omega.-sulfonate)alkoxy or (.omega.-sulfonic acid)alkoxy groups and water-soluble polythiophenes bearing (.omega.-sulfonic acid)-alkoxy side-chains prepared therefrom. The invention also relates to methods for the preparation of these compounds and to antistatic coatings and EMI shieldings comprising the polythiophenes.

  这项发明涉及带有(.omega.-磺酸酯)烷氧基或(.omega.-磺酸)烷氧基基团的噻吩，以及由此制备的带有(.omega.-磺酸)烷氧基侧链的水溶性聚噻吩。该发明还涉及这些化合物的制备方法，以及包含聚噻吩的防静电涂层和EMI屏蔽。
• Disassembly of conjugated polyelectrolyte aggregates and their application for colorimetric detection of surfactants in water
  作者：Zhiyi Yao、Yugang Li、Chun Li、Gaoquan Shi

  DOI：10.1039/c0cc02678f

  日期：——

  A colorimetric strategy based on conjugated polyelectrolyte aggregates has been applied to determine and distinguish anionic, cationic and non-ionic surfactants.

  基于共轭聚电解质聚集体的比色策略已被应用于检测和区分阴离子、阳离子和非离子表面活性剂。
• New Colorimetric and Fluorometric Chemosensor Based on a Cationic Polythiophene Derivative for Iodide-Specific Detection
  作者：Hoang A. Ho、Mario Leclerc

  DOI：10.1021/ja028765p

  日期：2003.4.1

  Electrostatic interactions between anions and a new water-soluble, cationic, affinitychromic poly(3-alkoxy-4-methylthiophene) derivative provide a new tool for a selective optical detection method (colorimetric or fluorometric) for iodide ions.

  阴离子与新的水溶性、阳离子、亲和变色聚（3-烷氧基-4-甲基噻吩）衍生物之间的静电相互作用为碘离子的选择性光学检测方法（比色法或荧光法）提供了一种新工具。
• Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
  申请人：Leclerc Mario

  公开号：US20060160124A1

  公开（公告）日：2006-07-20

  Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and single-stranded or double-stranded (hybridized) oligonucleotides.

  本发明揭示了一种简单的光学和电化学检测双链寡核苷酸的新方法。该方法快速、选择性和多功能。优点在于，它们不需要对探针或分析物进行任何化学反应，因为它们基于阳离子聚（3-烷氧基-4-甲基噻吩）衍生物与单链或双链（杂交）寡核苷酸之间的不同静电相互作用。
• DETECTION OF NEGATIVELY CHARGED POLYMERS USING WATER-SOLUBLE, CATIONIC, POLYTHIOPHENE DERIVATIVES
  申请人：Leclerc Mario

  公开号：US20100035272A1

  公开（公告）日：2010-02-11

  Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and single-stranded or double-stranded (hybridized) oligonucleotides.

  本发明公开了一种简单的光学和电化学检测双链寡核苷酸的新方法。该方法快速、选择性和多功能。优点在于，它们不需要在探针或分析物上进行任何化学反应，因为它们基于阳离子聚（3-烷氧基-4-甲基噻吩）衍生物与单链或双链（杂交）寡核苷酸之间的不同静电相互作用。